Wei-Yu Chen, Ph.D.中文網頁
Institute of Basic Medical Sciences, National Cheng Kung University (2009)
Immunology, cardiovascular and renal diseases, disease animal models, tissue fibrosis.
In our lab, we use genetically modified animals, disease animal models, and multi-omics approaches to investigate the immune regulation on tissue reparative responses following acute cardiac or kidney injury.
- Study of Interleukin-33-regulated immune network in acute myocardial injury and chronic kidney disease-associated cardiomyopathy progression.
- Therapeutic targeting regulated cell death (necroptosis, pyroptosis, and ferroptosis)- activated necroinflammation in acute kidney injury to promote tissue repair.
- Tzeng YR, Lee CH, Chen WY, Yang JL, Tzeng HT*. Inhibition of plasminogen activator inhibitor-1 blocks programmed death ligand 1 endocytosis and improves the response of melanoma cells to immune checkpoint blockade. Journal of Investigative Dermatology. 2021 Nov;141(11):2690-2698. [Abstract]
- Su CH, Hsu YC, Thangudu S, Chen WY, Huang YT, Yu CC, Shih YH, Wang CJ, Lin CL*. Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy. Scientific Reports. 2021, 11(1):1909. [Abstract]
- Chen WY*, Wu YH, Tsai TH, Li RF, Lai AC, Li LC, Yang JL, Chang YJ*. Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis. Theranostics 2021, 11(6):2594-2611. [Abstract]
- Lu SW, Pan HC, Hsu YH, Chang KC, Wu LW, Chen WY, Chang MS*. IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Nature Communications. 2020, 11(1):4611. [Abstract]
- Yang JL, Chen WY, Mukda S, Yang YR, Sun SF, Chen SD*. Oxidative DNA damage is concurrently repaired by BER and APE1-initiated NHEJ in cortical neurons. Neuropathology and Applied Neurobiology. 2020, 46(4):375-390. [Abstract]
- Wu YH, Lai AC, Chi PY, Thio CL, Chen WY, Tsai CH, Lee YL, Lukacs NW, Chang YJ*. Pulmonary IL-33 orchestrates innate immune cells to mediate RSV-evoked airway hyperreactivity and eosinophilia. Allergy. 2020, 75(4):818-830. [Abstract]
- Chen WY*. Soluble alpha-Klotho alleviates cardiac fibrosis without altering cardiomyocytes renewal. International Journal of Molecular Sciences. 2020, 21(6). pii: E2186. [Abstract]
- Chen WY, Li LC, Wu YH, Yang JL, Tzeng HT*. Emerging roles of interleukin-33-responsive kidney group 2 innate lymphoid cells in acute kidney injury. International Journal of Molecular Sciences. 2020, 21(4). pii: E1544. [Abstract]
- Tsai TH, Lin CJ, Hang CL, Chen WY*. Calcitriol attenuates doxorubicin-induced cardiac dysfunction and inhibits endothelial-to-mesenchymal transition in mice. Cells. 2019, 8(8). pii: E865. [Abstract]
- Tsai TH, Lee CH, Cheng CI, Chua S, Chung SY, Chen, SM, Lin CJ, Wu CJ, Hang CL, Chen WY *. Liraglutide inhibits endothelial-to-mesenchymal transition and attenuates neointima formation after endovascular injury in streptozotocin-induced diabetic mice. Cells. 2019, 8(6). pii: E589. [Abstract]
- Sung HY, Chen WY, Huang HT, Wang CY, Chang SB, Tzeng SF. Downregulation of interleukin-33 expression in oligodendrocyte precursor cells impairs oligodendrocyte lineage progression. Journal of Neurochemistry. 2019, 150(6):691-708. [Abstract]
- Weng YH+, Chen WY+, Lin YL, Wang JY*, and Chang MS*. Blocking IL-19 signaling ameliorates allergen-induced airway inflammation. Frontiers in Immunology. 2019, 19:968. [Abstract]
- Li LC, Yang JL, Lee WC, Chen JB, Lee CT, Wang PW, Vaghese Z, Chen WY*. Palmitate aggravates proteinuria-induced cell death and inflammation via CD36-inflammasome axis in the proximal tubular cells of obese mice. American Journal of Physiology-Renal Physiology 2018, 315(6) F1720-F1731. [Abstract]
- Chen WY*, Yang JL, Wu YH, Li LC, Li RF, Chang YT, Dai LH, Wang WC, Chang YJ*. IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury.Experimental and Molecular Medicine. 2018 Apr 20;50(4):1-11. [Abstract]
- Chen WY, Li LC, Yang JL*. Emerging roles of IL-33/ST2 axis in renal diseases. International Journal of Molecular Sciences. 2017, 18(4): pii: E783. [Abstract]
- Yang JL, Chen WY, Chen YP, Kuo CY, Chen SD*. Activation of GLP-1 receptor enhances neuronal base excision repair via PI3K-AKT-induced expression of apurinic/apyrimidinic endonuclease 1. Theranostics. 2016, 6(12): 2015-2027. [Abstract]
- Su CH+, Tsai CY+, Tomanek B, Chen WY, Cheng FY*. Evaluation of blood-brain barrier-stealth nanocomposites for in situ glioblastoma theranostics applications. Nanoscale. 2016, 8(15): 7866-7870. [Abstract]
- Chen WY*, Chang YJ, Su CH, Tsai TH, Chen SD, Hsing CH, Yang JL*. Upregulation of Interleukin-33 in obstructive renal injury. Biochemical and Biophysical Research Communications. 2016, 473(4): 1026-1032. [Abstract]
- Chen WY, Hong J, Gannon J, Kakkar R, Lee RT*. Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33. Proceedings of the National Academy of Sciences of the United States of America. 2015, 112(23): 7249-7254. [Abstract]
- Ho JE+, Chen WY+, Chen MH, Larson MG, McCabe EL, Cheng S, Ghorbani A, Coglianese E, Emilsson V, Johnson AD, Walter S, Franceschini N, O'Donnell CJ; CARDIoGRAM Consortium; CHARGE Inflammation Working Group, Dehghan A, Lu C, Levy D, Newton-Cheh C; CHARGE Heart Failure Working Group, Lin H, Felix JF, Schreiter ER, Vasan RS, Januzzi JL, Lee RT, Wang TJ. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. Journal of Clinical Investigation. 2013, 123(10): 4208-4218. [Abstract]
- Chen WY, Lee RT. Endothelial cardiac cell therapy: large-animal studies and the elephant in the room. Circulation Research. 2012, 111(7):824-6. [Abstract]
- Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. Journal of Experimental Medicine. 2011, 208(9):1849-61. [Abstract]
- Chen WY, Chang MS. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. Journal of Immunology. 182(8):5003-12. [Abstract]
- Chen WY, Cheng BC, Jiang MJ, Hsieh MY, Chang MS. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006, 26(9):2090-5. [Abstract]
- Chen WY, Cheng YT, Lei HY, Chang CP, Wang CW, Chang MS. IL-24 inhibits the growth of hepatoma cells in vivo. Genes and Immunity. 2005, 6(6):493-9. [Abstract]