成大 生化所
陳威宇 副教授

Associate Professor Wei-Yu Chen

English Main Page
通訊地址： 701 台南市大學路一號 國立成功大學醫學院九樓生化所
連絡電話： 申請中
E-mail： wychen624@gmail.com

學歷
國立成功大學基礎醫學研究所 博士 (2009)

研究專長
免疫學、心血管與腎臟疾病、疾病動物模式、組織纖維化

研究方向與研究興趣
應用基因修飾小鼠、疾病動物模式、多體學分析等策略研究心臟或腎臟組織損傷後，免疫系統參與組織修復反應之調控，並尋找具有潛力的治療標的。

研究主題

Publications:

  1. Tzeng YR, Lee CH, Chen WY, Yang JL, Tzeng HT*. Inhibition of plasminogen activator inhibitor-1 blocks programmed death ligand 1 endocytosis and improves the response of melanoma cells to immune checkpoint blockade. Journal of Investigative Dermatology. 2021 Nov;141(11):2690-2698. [Abstract]
  2. Su CH, Hsu YC, Thangudu S, Chen WY, Huang YT, Yu CC, Shih YH, Wang CJ, Lin CL*. Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy. Scientific Reports. 2021, 11(1):1909. [Abstract]
  3. Chen WY*, Wu YH, Tsai TH, Li RF, Lai AC, Li LC, Yang JL, Chang YJ*. Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis. Theranostics 2021, 11(6):2594-2611. [Abstract]
  4. Lu SW, Pan HC, Hsu YH, Chang KC, Wu LW, Chen WY, Chang MS*. IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Nature Communications. 2020, 11(1):4611. [Abstract]
  5. Yang JL, Chen WY, Mukda S, Yang YR, Sun SF, Chen SD*. Oxidative DNA damage is concurrently repaired by BER and APE1-initiated NHEJ in cortical neurons. Neuropathology and Applied Neurobiology. 2020, 46(4):375-390. [Abstract]
  6. Wu YH, Lai AC, Chi PY, Thio CL, Chen WY, Tsai CH, Lee YL, Lukacs NW, Chang YJ*. Pulmonary IL-33 orchestrates innate immune cells to mediate RSV-evoked airway hyperreactivity and eosinophilia. Allergy. 2020, 75(4):818-830. [Abstract]
  7. Chen WY*. Soluble alpha-Klotho alleviates cardiac fibrosis without altering cardiomyocytes renewal. International Journal of Molecular Sciences. 2020, 21(6). pii: E2186. [Abstract]
  8. Chen WY, Li LC, Wu YH, Yang JL, Tzeng HT*. Emerging roles of interleukin-33-responsive kidney group 2 innate lymphoid cells in acute kidney injury. International Journal of Molecular Sciences. 2020, 21(4). pii: E1544. [Abstract]
  9. Tsai TH, Lin CJ, Hang CL, Chen WY*. Calcitriol attenuates doxorubicin-induced cardiac dysfunction and inhibits endothelial-to-mesenchymal transition in mice. Cells. 2019, 8(8). pii: E865. [Abstract]
  10. Tsai TH, Lee CH, Cheng CI, Chua S, Chung SY, Chen, SM, Lin CJ, Wu CJ, Hang CL, Chen WY *. Liraglutide inhibits endothelial-to-mesenchymal transition and attenuates neointima formation after endovascular injury in streptozotocin-induced diabetic mice. Cells. 2019, 8(6). pii: E589. [Abstract]
  11. Sung HY, Chen WY, Huang HT, Wang CY, Chang SB, Tzeng SF. Downregulation of interleukin-33 expression in oligodendrocyte precursor cells impairs oligodendrocyte lineage progression. Journal of Neurochemistry. 2019, 150(6):691-708. [Abstract]
  12. Weng YH+, Chen WY+, Lin YL, Wang JY*, and Chang MS*. Blocking IL-19 signaling ameliorates allergen-induced airway inflammation. Frontiers in Immunology. 2019, 19:968. [Abstract]
  13. Li LC, Yang JL, Lee WC, Chen JB, Lee CT, Wang PW, Vaghese Z, Chen WY*. Palmitate aggravates proteinuria-induced cell death and inflammation via CD36-inflammasome axis in the proximal tubular cells of obese mice. American Journal of Physiology-Renal Physiology 2018, 315(6) F1720-F1731. [Abstract]
  14. Chen WY*, Yang JL, Wu YH, Li LC, Li RF, Chang YT, Dai LH, Wang WC, Chang YJ*. IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury.Experimental and Molecular Medicine. 2018 Apr 20;50(4):1-11. [Abstract]
  15. Chen WY, Li LC, Yang JL*. Emerging roles of IL-33/ST2 axis in renal diseases. International Journal of Molecular Sciences. 2017, 18(4): pii: E783. [Abstract]
  16. Yang JL, Chen WY, Chen YP, Kuo CY, Chen SD*. Activation of GLP-1 receptor enhances neuronal base excision repair via PI3K-AKT-induced expression of apurinic/apyrimidinic endonuclease 1. Theranostics. 2016, 6(12): 2015-2027. [Abstract]
  17. Su CH+, Tsai CY+, Tomanek B, Chen WY, Cheng FY*. Evaluation of blood-brain barrier-stealth nanocomposites for in situ glioblastoma theranostics applications. Nanoscale. 2016, 8(15): 7866-7870. [Abstract]
  18. Chen WY*, Chang YJ, Su CH, Tsai TH, Chen SD, Hsing CH, Yang JL*. Upregulation of Interleukin-33 in obstructive renal injury. Biochemical and Biophysical Research Communications. 2016, 473(4): 1026-1032. [Abstract]
  19. Chen WY, Hong J, Gannon J, Kakkar R, Lee RT*. Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33. Proceedings of the National Academy of Sciences of the United States of America. 2015, 112(23): 7249-7254. [Abstract]
  20. Ho JE+, Chen WY+, Chen MH, Larson MG, McCabe EL, Cheng S, Ghorbani A, Coglianese E, Emilsson V, Johnson AD, Walter S, Franceschini N, O'Donnell CJ; CARDIoGRAM Consortium; CHARGE Inflammation Working Group, Dehghan A, Lu C, Levy D, Newton-Cheh C; CHARGE Heart Failure Working Group, Lin H, Felix JF, Schreiter ER, Vasan RS, Januzzi JL, Lee RT, Wang TJ. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. Journal of Clinical Investigation. 2013, 123(10): 4208-4218. [Abstract]
  21. Chen WY, Lee RT. Endothelial cardiac cell therapy: large-animal studies and the elephant in the room. Circulation Research. 2012, 111(7):824-6. [Abstract]
  22. Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. Journal of Experimental Medicine. 2011, 208(9):1849-61. [Abstract]
  23. Chen WY, Chang MS. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. Journal of Immunology. 182(8):5003-12. [Abstract]
  24. Chen WY, Cheng BC, Jiang MJ, Hsieh MY, Chang MS. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006, 26(9):2090-5. [Abstract]
  25. Chen WY, Cheng YT, Lei HY, Chang CP, Wang CW, Chang MS. IL-24 inhibits the growth of hepatoma cells in vivo. Genes and Immunity. 2005, 6(6):493-9. [Abstract]