成大生化所
劉卜慈 助理教授

Assistant Professor Pu-Ste Liu

English Main Page
通訊地址： 701 台南市大學路一號
連絡分機： 5514(辦公室) 5551(實驗室)
E-mail： z11302014@ncku.edu.tw

學歷
國立成功大學基礎醫學研究所 博士 (2003 - 2010)
國立成功大學生物化學暨分子生物學研究所 碩士 (2000 - 2002)
中國醫學大學醫學檢驗生物技術學系 學士 (1996 - 2000)

經歷
國立成功大學生物化學暨分子生物學研究所 助理教授 (2024 - present)
國家衛生研究院，細胞及系統醫學研究所 助研究員 (2018 - 2024)
University of Lausanne 博士後研究員 (2015 - 2018)
University of Minnesota 博士後研究員 (2011 - 2014)
國立成功大學藥理學研究所博士後研究員 (2010 - 2011)

專長領域
免疫學、免疫代謝體學、代謝症候群、腫瘤免疫學

研究興趣
我們的研究探討巨噬細胞免疫代謝在調節慢性炎症性疾病和疾病發展中的作用，尤其著重於代謝綜合症（二型糖尿病、胰島素抵抗和動脈粥樣硬化）以及癌症。我們利用轉錄體學、代謝體學和表觀基因組學的綜合方法，以釐清影響巨噬細胞在疾病進程中活化和功能的代謝檢查點和調控分子機制。特別聚焦於針對疾病微環境，如糖尿病患者的脂肪組織、動脈粥樣硬化的動脈微環境和腫瘤組織中，造成影響巨噬細胞失調的免疫代謝分子機轉。我們致力於瞭解在這些疾病條件下，免疫代謝如何影響脂肪組織巨噬細胞，動脈粥樣硬化巨噬細胞和腫瘤巨噬細胞的功能，並且有意將焦點放在靶向脂肪組織巨噬細胞,動脈粥樣硬化巨噬細胞和腫瘤巨噬細胞的免疫代謝迴路，以改善巨噬細胞免疫和功能以達到改善疾病結果。

目前實驗室兩個主要研究方向 :
1.探討訓練免疫在肥胖和肥胖所引發動脈粥狀硬化的機轉
2.解構粒線體調控腫瘤巨噬細胞免疫反應及功能之機轉

Publications:

  1. Liu PS*, Chen YT, Li XY, Hsueh PC, Tzeng SF, Shi PZ, Xie X, Parik S, Fendt S-M, Ho PC*. CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions. Nature Immunology, 2023, 24, 452-62.

  2. Raines LN, Zhao H, Wang Y, Chen H-Y, Gallart-Ayala H, Hsueh P-C, Cao W, Koh Y, Alamonte-Loya A, Liu PS, Ivanisevic J, Lio C-WJ, Ho P-C, Huang SC-C. PERK is a critical metabolic hub for immunosuppressive function in macrophages. Nature Immunology, 2022, 23, 431–445.

  3. Yu YR, Imrichova H, Wang H, Chao T, Xiao Z, Gao M, Rincon-Restrepo M, Franco F, Genolet R, Cheng WC, Jandus C, Coukos G, Jiang YF, Lo-casale JW, Zippelius A, Liu PS, Tang L, Bock C, Vannini N, Ho PC. Disturbed mitochondrial dynamics in CD8 + TILs reinforce T cell exhaustion. Nature Immunology, 2021, 21, 1540–1551.

  4. Xie X, Liu PS, Percipalle P. Analysis of global transcriptome changes in mouse embryonic fibroblasts after dsDNA and dsRNA viral mimic stimulation. Frontiers in Immunology, section Molecular Innate Immunity, 2019, 17, April.

  5. Liu PS, Ho PC. Determining macrophage polarization upon metabolic perturbation. Methods in Molecular Biology, 2018 ;1862; 173-186.

  6. Liu PS*, Ho PC. Mitochondria: A master regulator in macrophage and T cell immunity. Mitochondrion, 2018; 41; 45-50.

  7. Lin YW, Liu PS, Pook KA, Wei LN. Glyburide and retinoic acid synergize to promote wound healing by anti- inflammation and RIP140 degradation. Scientific Reports, 2018; 8; 834.

  8. Liu PS, Wang HP, Li XY, Chao T, Teav T, Christen S, Di Conza G, Chen WC, Chou CH, Vavakova M, Muret C, Debackere K, Mazzone M, Hung HD, Maria-Fendt S, Ivanisevic J, Ho PC. Integration of a-ketoglutarate/succinate balance controls macrophage polarization through immunometabolic and epigenetic reprogramming. Nature Immunology, 2017; 18; 985-994.

  9. Ho PC, Liu PS. Metabolic communication in tumors: a new layer of immunoregulation for immune evasion. Journal for Immunotherapy of Cancer, 2016; 4: 4.

  10. Lin YW, Lee B, Liu PS, Wei LN. Receptor-interacting protein 140 orchestrates the dynamics of macrophage M1/M2 polarization. Journal of Innate Immunity, 2016; 8: 97-107.

  11. Liu PS, Lin YW, Burton FH, Wei LN. Injecting engineered anti-inflammatory macrophages therapeutically induces white adipose tissue browning and improves diet-induced insulin resistance. Adipocyte, 2015; 4: 123-128.

  12. Liu PS, Lin YW, Burton FH, Wei LN. M1-M2 balancing act in white adipose tissue browning – a new role for RIP140. Adipocyte, 2015; 4: 146-148.

  13. Lin YW, Liu PS, Adhikari N, Hall JL, Wei LN. RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages. Journal of Molecular and Cellular Cardiology, 2015; 79: 287-294.

  14. Liu PS, Lin YW, Lee B, McCrady-Spitzer SK, Levine JA, Wei LN. Reducing RIP140 expression in macrophage alters ATM infiltration, facilitates white adipose tissue browning and prevents high fat diet-induced insulin resistance. Diabetes, 2014; 63: 4021-4031.

  15. Liu PS, Jong TH, Maa MC, Leu TH. The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation. Oncogene, 2010; 29: 3977-89.

  16. Shiau AL, Liu PS and Wu CL. Novel strategy for generation and titration of recombinant adeno-associated virus vectors. Journal of Virology, 2005; 79: 193-201.