成大生化所
陳伯翰 助理教授

Assistant Professor Po-Han Chen

通訊地址： 01 台南市大學路一號
E-mail： po-han.chen.pc673@yale.edu

學歷
美國杜克大學 博士 (2018)

專長領域
● 分子生物學

研究興趣
　　Targeted protein degradation (PROTAC) and dephosphorylation (PhosTAC)

Publications:

  1. Po-Han Chen, Jonathan Hong, Jen-Tsan Chi. 2017/3/1 Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs. Current Pathobiology Reports. 5(1):43-48
  2. Po-Han Chen, Timothy J. Smith, Jianli Wu, Priscila F. Siesser, Farhan Khan, Maxwell Hogue, Erik Soderblom, Flora Tang, Jeffrey R. Marks, Michael B. Major, Benjamin M. Swarts, Michael Boyce and Jen-Tsan Chi. 2017/08/01 Glycosylation of KEAP1 links nutrient sensing to redox stress signaling. The EMBO journal. 36 (15):2233-2250
  3. Po-Han Chen, Jen-Tsan Chi and Michael Boyce. 2017/11/2 KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells. Molecular and Cellular Oncology. 4(6):e1361501
  4. Po-Han Chen, Jen-Tsan Chi and Michael Boyce. 2018/8 Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways. Glycobiology. 28(8):556-564
  5. Po-Han Chen, Jimin Hu, Jianli Wu, Duc T. Huynh, Timothy J. Smith, Samuel Pan, Brittany J. Bisnett, Alexander B. Smith, Annie Lu, Brett M. Condon, Jen-Tsan Chi, and Michael Boyce. 2020/1/16 Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. JCI insight. 5(1)
  6. Po-Han Chen, Jianli Wu, Chien-Kuang Cornelia Ding, Chao-Chieh Lin, Samuel Pan, Nathan Bossa, Yitong Xu, Wen-Hsuan Yang, Bernard Mathey-Prevot, Jen-Tsan Chi. 2020/3 Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism. Cell Death and Differentiation. 27(3):1008-1022
  7. Chien-Kuang Cornelia Dingǂ, Joshua Roseǂ, Tianai Sunǂ, Jianli Wu, Po-Han Chen, Chao-Chieh Lin, Wen-Hsuan Yang, Kai-Yuan Chen, Hana Lee, Emily Xu, Sarah Tian, Jadesola Akinwuntan, Jinshi Zhao, Ziqiang Guan, Pei Zhou and Jen-Tsan Chi. 2020/3 MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. Nature Metabolism. 2(3):270-277
  8. Po-Han Chen, Watson Hua-Sheng Tseng, and Jen-Tsan Chi. 2020/8 The intersection of DNA damage response and ferroptosis- a rational for combination therapeutics. Biology-Basel. 9(8):187
  9. Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic. 2021/2/15 A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and notch signaling. Biology Open. 10(2):bio050211
  10. Po-Han Chen, Jianli Wu, Yitong Xu, Chien-Kuang Cornelia Ding, Alexander A. Mestre, Chao-Chieh Lin, Wen-Hsuan Yang, and Jen-Tsan Chi. 2021/2/19 Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death and Disease. 12(2):1-12
  11. Chao-Chieh Lin, Wen-Hsuan Yang, Yi-Tzu Lin, Xiaohu Tang, Po-Han Chen, Chien-Kuang Ding, Dan Chen Qu, James V. Alvarez and Jen-Tsan Chi. 2021/3 EMT-driven DDR2 expression in breast cancer regulates ferroptosis through the Hippo pathway. Oncogene. 40(11):2018-2034
  12. Wen-Hsuan Yang, Chao-Chieh Lin, Jianli Wu, Pei-Ya Chao, Kuan Chen, Po-Han Chen, and Jen-Tsan Chi. 2021/6/1 The Hippo pathway effector YAP promotes ferroptosis via the E3 Ligase SKP2. Molecular Cancer Research. 19(6):1005-1014
  13. Po-Han Chen, Jen-Tsan Chi. 2021/6/8 Unexpected zinc dependency of ferroptosis – what is in a name? Oncotarget. 12(12):1126
  14. Po-Han Chen, Zhenyi Hu, Elvira An, Ifunanya Okeke, Sijin Zheng, Xuanmeng Luo, Angela Gong, Saul Jaime-Figureroa, Craig M Crews. 2021/11/15 Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs). ACS Chemical Biology. 16, 12, 2808-2815
  15. Po-Han Chen, Timothy J Smith, Jianli Wu, Michael Boyce, Jen-Tsan Ashley Chi. 2017/07/01 OGT restrains the NRF2 antioxidant pathway via O-GlcNAcylation of KEAP1. Cancer Research. 77(13S):5457-5457, USA
  16. Po-Han Chen, Timothy J Smith, Michael Boyce, and Jen-Tsan Chi. 2018/6/10 Metabolic regulation of Kelch-Like (KLHL) proteins through O-glycosylation Gordon Research Conference on Bioorganic Chemistry meeting. USA
  17. Po-Han Chen, Timothy J Smith, Jen-Tsan Ashley Chi, Michael Boyce. 2018/9/24 O-GlcNAcylation of gigaxonin regulates intermediate filaments and giant axonal neuropathy Triangle Cytoskeleton Meeting. USA
  18. Duc T Huynh, Po-Han Chen, Jimin Hu, Timothy J Smith, Jen-Tsan Chi, Michael S Boyce. 2020/4 Kelch-like proteins have a sweet spot: site-specific glycosylation influences metabolic regulation and protein homeostasis. The FASEB Journal. 34(S1):1-1, USA