成大耳鼻喉學科
蕭振仁 教授

Professor Jenn-Ren Hsiao

通訊地址： 70101臺南市東區大學路一號
連絡電話： (06)2353535#5311
E-mail： hsiaojr@mail.ncku.edu.tw

學歷
國立成功大學臨床醫學研究所博士 (2004)

經歷
1996年8月~1999年7月 國立成功大學附設醫院耳鼻喉部主治醫師
1999年8月~2003年7月 國立成功大學耳鼻喉科臨床講師
2003年8月~2009年7月 國立成功大學耳鼻喉科臨床助理教授
2009年8月~2013年7月 國立成功大學耳鼻喉科臨床副教授
2013年8月~2015年7月 國立成功大學耳鼻喉科臨床教授
2015年8月~迄今 國立成功大學耳鼻喉科教授

專長領域
頭頸腫瘤學
轉譯醫學
基因流行病學
一般耳鼻喉科學

Publications:

  1. Esophageal reconstruction after oncological total laryngopharyngoesophagectomy: Algorithmic approachChang, T. Y., Hsiao, J. R., Lee, W. T., Ou, C. Y., Yen, Y. T., Tseng, Y. L., Pan, S. C., Shieh, S. J. & Lee, Y. C., 2019 一月, 於 : Microsurgery. 39, 1, p. 6-13 8 p.
  2. Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cellsWang, S. H., Liou, G. G., Liu, S. H., Chang, J. S., Hsiao, J. R., Yen, Y. C., Chen, Y. L., Wu, W. L., Chang, J. Y. & Chen, Y. W., 2019 六月 1, 於 : International Journal of Cancer. 144, 11, p. 2795-2810 16 p.
  3. MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1Chou, S. T., Peng, H. Y., Mo, K. C., Hsu, Y. M., Wu, G. H., Hsiao, J. R., Lin, S. F., Wang, H. D. & Shiah, S. G., 2019 六月 28, 於 : Journal of Experimental and Clinical Cancer Research. 38, 1, 281.
  4. Oral hygiene and the overall survival of head and neck cancer patientsChang, C. C., Lee, W. T., Hsiao, J. R., Ou, C. Y., Huang, C. C., Tsai, S. T., Chen, K. C., Huang, J. S., Wong, T. Y., Lai, Y. H., Wu, Y. H., Hsueh, W. T., Wu, S. Y., Yen, C. J., Chang, J. Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2019 四月, 於 : Cancer medicine. 8, 4, p. 1854-1864 11 p.
  5. Resected specimen size: A reliable predictor of severe Frey syndrome after parotidectomyLin, H. J., Hsiao, J-R., Chang, J. S., Hu, C. L., Chen, T. R., Lee, W-T., Huang, C-C., Ou, C-Y., Tsai, S-W., Lu, Y. C., Tsai, S-T., Chao, W-Y. & Chang, C-C., 2019 七月 1, 於 : Head and Neck. 41, 7, p. 2285-2290 6 p.
  6. The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patientsLee, W. T., Hsiao, J. R., Ou, C. Y., Huang, C. C., Chang, C. C., Tsai, S. T., Chen, K. C., Huang, J. S., Wong, T. Y., Lai, Y. H., Wu, Y. H., Hsueh, W. T., Wu, S. Y., Yen, C. J., Chang, J. Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2019 二月, 於 : Cancer Epidemiology Biomarkers and Prevention. 28, 2, p. 248-257 10 p.
  7. TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motilityHsing, E. W., Shiah, S. G., Peng, H. Y., Chen, Y. W., Chuu, C. P., Hsiao, J. R., Lyu, P. C. & Chang, J. Y., 2019 三月, 於 : PloS one. 14, 3, e0213463.
  8. Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case–Control Study of Head and Neck CancerHsiao, J-R., Lee, W-T., Ou, C-Y., Huang, C-C., Chang, C-C., Tsai, S-T., Chen, K-C., Huang, J-S., Wang, D-Y., Lai, Y-H., Wu, Y-H., Hsueh, W-T., Wu, S-Y., Yen, C-J., Chang, J-Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2019 六月 1, 於 : Alcoholism: Clinical and Experimental Research. 43, 6, p. 1225-1233 9 p.
  9. Intensive Care Unit Versus Ward Management After Anterolateral Thigh Flap Reconstruction After Oral Cancer AblationChen, W. C., Hung, K. S., Chen, S. H., Shieh, S. J., Lee, J. W., Hsiao, J. R. & Lee, Y. C., 2018 二月 1, 於 : Annals of plastic surgery. 80, 2S Suppl 1, p. S11-S14
  10. The interplay between oral microbiome, lifestyle factors and genetic polymorphisms in the risk of oral squamous cell carcinomaHsiao, J-R., Chang, C-C., Lee, W-T., Huang, C-C., Ou, C-Y., Tsai, S-T., Chen, K-C., Huang, J-S., Wang, D-Y., Lai, Y-H., Wu, Y-H., Hsueh, W-T., Wu, S-Y., Yen, C-J., Chang, J-Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2018 五月 28, 於 : Carcinogenesis. 39, 6, p. 778-787 10 p.
  11. ALDH2 polymorphism and alcohol-related cancers in Asians: A public health perspective Tse-Hua TanChang, J. S., Hsiao, J. R. & Chen, C. H., 2017 三月 3, 於 : Journal of biomedical science. 24, 1, 19.
  12. Investigating the Association between Alcohol and Risk of Head and Neck Cancer in TaiwanHuang, C. C., Hsiao, J. R., Lee, W. T., Lee, Y. C., Ou, C. Y., Chang, C. C., Lu, Y. C., Huang, J. S., Wong, T. Y., Chen, K. C., Tsai, S. T., Fang, S. Y., Wu, J. L., Wu, Y. H., Hsueh, W. T., Yen, C. J., Wu, S. Y., Chang, J. Y., Lin, C. L., Wang, Y. H. 及其他4, , 2017 十二月 1, 於 : Scientific reports. 7, 1, 9701.
  13. Investigating the association between diet and risk of head and neck cancer in TaiwanChang, C. C., Lee, W. T., Lee, Y. C., Huang, C. C., Ou, C. Y., Lin, Y. H., Huang, J. S., Wong, T. Y., Chen, K. C., Hsiao, J. R., Lu, Y. C., Tsai, S. T., Lai, Y. H., Wu, Y. H., Hsueh, W. T., Yen, C. J., Wu, S. Y., Chang, J. Y., Fang, S. Y., Wu, J. L. 及其他5, , 2017 一月 1, 於 : Oncotarget. 8, 58, p. 98865-98875 11 p.
  14. Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 RegulationChang, W. M., Lin, Y. F., Su, C. Y., Peng, H. Y., Chang, Y. C., Hsiao, J. R., Chen, C. L., Chang, J. Y., Shieh, Y. S., Hsiao, M. & Shiah, S. G., 2017 一月 25, 於 : Scientific reports. 7, 41131.
  15. Patch esophagoplasty with a free proximal lateral leg flap for focal stricture of the cervical esophagus: A case reportLin, Y. C., Hsiao, J. R. & Lee, Y. C., 2017 七月, 於 : Microsurgery. 37, 5, p. 426-430 5 p.
  16. Regular recreational physical activity and risk of head and neck cancerLin, C. L., Lee, W. T., Ou, C. Y., Hsiao, J. R., Huang, C. C., Huang, J. S., Wong, T. Y., Chen, K. C., Tsai, S. T., Fang, S. Y., Huang, T. T., Wu, J. L., Wu, Y. H., Hsueh, W. T., Yen, C. J., Lai, Y. H., Liao, H. C., Wu, S. Y., Yang, M. W., Lin, F. C. 及其他6, , 2017 四月 21, 於 : BMC cancer. 17, 1, 286.
  17. Total maxillary reconstruction with a bi-paddle double-barrel osteocutaneous fibular flap and arteriovenous saphenous loop after a globe-sparing total maxillectomy due to osteosarcomaTseng, W. L., Chang, T. Y., Hung, K. S., Chen, S. H., Hsiao, J. R. & Lee, Y. C., 2017 一月 1, 於 : Journal of Craniofacial Surgery. 28, 1, p. 193-196 4 p.
  18. Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cellsWang, S. H., Chang, J. S., Hsiao, J. R., Yen, Y. C., Jiang, S. S., Liu, S. H., Chen, Y. L., Shen, Y. Y., Chang, J. Y. & Chen, Y. W., 2017 三月 1, 於 : Oncogene. 36, 11, p. 1503-1515 13 p.
  19. A 16-year experience in treating thyroglossal duct cysts with a “conservative” Sistrunk approachZhu, Y. S., Lee, C-T., Ou, C-Y., Wu, J-L., Chao, W-Y., Tsai, S-T., Fang, S-Y., Huang, C-C., Lee, W-T., Chang, J. S. & Hsiao, J-R., 2016 四月 1, 於 : European Archives of Oto-Rhino-Laryngology. 273, 4, p. 1019-1025 7 p.
  20. A comprehensive analysis on the association between tobacco-free betel quid and risk of head and neck cancer in Taiwanese menWu, Y. H., Yen, C. J., Hsiao, J. R., Ou, C. Y., Huang, J. S., Wong, T. Y., Tsai, S. T., Huang, C. C., Lee, W. T., Chen, K. C., Fang, S. Y., Wu, J. L., Hsueh, W. T., Lin, F. C., Yang, M. W., Chang, J. Y., Liao, H. C., Wu, S. Y., Lin, C. L., Wang, Y. H. 及其他4, , 2016 十月, 於 : PloS one. 11, 10, 0164937.
  21. Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancerLiao, H. C., Wu, S-Y., Ou, C-Y., Hsiao, J-R., Huang, J-S., Tsai, S-T., Huang, C-C., Wang, D-Y., Lee, W-T., Chen, K-C., Fang, S-Y., Wu, J-L., Huang, T-T., Wu, Y-H., Hsueh, W-T., Yen, C-J., Yang, M-W., Lin, F-C., Lai, Y-H., Chang, J-Y. 及其他6, , 2016 九月 1, 於 : Cancer Causes and Control. 27, 9, p. 1105-1115 11 p.
  22. Cost effectiveness of cancer treatment in TaiwanHung, M. C., Lai, W. W., Chen, H. H. W., Lee, J. C., Lin, Y. J., Hsiao, J. R., Cheng, Y. M., Shan, Y. S., Su, W. C. & Wang, J. D., 2016 八月 1, 於 : Journal of the Formosan Medical Association. 115, 8, p. 609-618 10 p.
  23. Dysregulation of RUNX2/activin-A axis upon miR-376c downregulation promotes lymph node metastasis in head and neck squamous cell carcinomaChang, W. M., Lin, Y. F., Su, C. Y., Peng, H. Y., Chang, Y. C., Lai, T. C., Wu, G. H., Hsu, Y. M., Chi, L. H., Hsiao, J. R., Chen, C. L., Chang, J. Y., Shieh, Y. S., Hsiao, M. & Shiah, S. G., 2016 十二月 15, 於 : Cancer Research. 76, 24, p. 7140-7150 11 p.
  24. Erratum to: Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin ß1 [Oncotarget. 2015; 6(39): 41837-41855.] DYen, Y. C., Hsiao, J. R., Jiang, S. S., Chang, J. S., Wang, S. H., Shen, Y. Y., Chen, C. H., Chang, I. S., Chang, J. Y. & Chen, Y. W., 2016 五月 31, 於 : Oncotarget. 7, 22, 1 p.
  25. IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinomaPeng, H. Y., Jiang, S. S., Hsiao, J. R., Hsiao, M., Hsu, Y. M., Wu, G. H., Chang, W. M., Chang, J. Y., Jin, S. L. C. & Shiah, S. G., 2016 六月 1, 於 : Molecular Oncology. 10, 6, p. 895-909 15 p.
  26. Integrin Targeted Gold Nanoparticles Potentiate Cancer Radiation Sensitivity: Synthesizing and modifying gold nanorods to target cancer cellsYeh, I. C., Wang, P. W., Liu, H. Y., Wu, P. C., Hsiao, J. R. & Shieh, D. B., 2016 三月 1, 於 : IEEE Nanotechnology Magazine. 10, 1, p. 4-15 12 p., 7387738.
  27. Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinomaCheng, C. W., Hsiao, J. R., Fan, C. C., Lo, Y. K., Tzen, C. Y., Wu, L. W., Fang, W. Y., Cheng, A. J., Chen, C. H., Chang, I. S., Jiang, S. S., Chang, J. Y. & Lee, A. Y. L., 2016 五月 1, 於 : Molecular Carcinogenesis. 55, 5, p. 499-513 15 p.
  28. One versus two venous anastomoses in anterolateral thigh flap reconstruction after oral cancer ablationLee, Y-C., Chen, W. C., Chen, S-H., Hong, K-S., Hsiao, J-R., Lee, J-W. & Shieh, S-J., 2016 八月 1, 於 : Plastic and Reconstructive Surgery. 138, 2, p. 481-489 9 p.
  29. Up-regulation of miR-455-5p by the TGF-β–SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2BCheng, C. M., Shiah, S. G., Huang, C. C., Hsiao, J. R. & Chang, J. Y., 2016 九月 1, 於 : Journal of Pathology. 240, 1, p. 38-49 12 p.
  30. Alcohol drinking obliterates the inverse association between serum retinol and risk of head and neck cancerChen, K. C., Hsueh, W. T., Ou, C. Y., Huang, C. C., Lee, W. T., Fang, S. Y., Tsai, S. T., Huang, J. S., Wong, T. Y., Wu, J. L., Yen, C. J., Wu, Y. H., Lin, F. C., Yang, M. W., Chang, J. Y., Liao, H. C., Wu, S. Y., Hsiao, J. R., Lin, C. L., Wang, Y. H. 及其他4, , 2015 七月 1, 於 : Medicine (United States). 94, 26, e1064.
  31. Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 productionFang, W. Y., Chen, Y. W., Hsiao, J. R., Liu, C. S., Kuo, Y. Z., Wang, Y. C., Chang, K. C., Tsai, S. T., Chang, M. Z., Lin, S. H. & Wu, L. W., 2015 一月 1, 於 : Oncotarget. 6, 29, p. 28401-28424 24 p.
  32. Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancerLee, W-T., Huang, C-C., Chen, K-C., Wang, D-Y., Ou, C-Y., Tsai, S-T., Yen, C-J., Fang, S-Y., Lo, H. I., Wu, Y-H., Hsueh, W-T., Yang, M-W., Lin, F-C., Hsiao, J-R., Huang, J-S., Chang, J-Y., Chang, K. Y., Wu, S-Y., Lin, C. L., Wang, Y. H. 及其他3, , 2015 三月 1, 於 : Oral Diseases. 21, 2, p. 207-215 9 p.
  33. IL-1β promotes malignant transformation and tumor aggressiveness in oral cancerLee, C. H., Chang, J. S. M., Syu, S. H., Wong, T. S., Chan, J. Y. W., Tang, Y. C., Yang, Z. P., Yang, W. C., Chen, C. T., Lu, S. C., Tang, P. H., Yang, T. C., Chu, P. Y., Hsiao, J. R. & Liu, K. J., 2015 四月 1, 於 : Journal of Cellular Physiology. 230, 4, p. 875-884 10 p.
  34. Incidence trends of human papillomavirus-related head and neck cancer in Taiwan, 1995-2009Hwang, T. Z., Hsiao, J. R., Tsai, C. R. & Chang, J. S., 2015 七月 15, 於 : International Journal of Cancer. 137, 2, p. 395-408 14 p.
  35. Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1Yen, Y. C., Hsiao, J. R., Jiang, S. S., Chang, J. S., Wang, S. H., Shen, Y. Y., Chen, C. H., Chang, I. S., Chang, J. Y. & Chen, Y. W., 2015 一月 1, 於 : Oncotarget. 6, 39, p. 41837-41855 19 p.
  36. Life expectancy and expected years of life lost to oral cancer in Taiwan: A nation-wide analysis of 22,024 cases followed for 10 yearsHuang, C. C., Ou, C. Y., Lee, W. T., Hsiao, J. R., Tsai, S. T. & Wang, J. D., 2015 一月 1, 於 : Oral Oncology. 51, 4, p. 349-354 6 p.
  37. Outcome analysis of condylar prosthesis in large head and neck neoplasm reconstructionHuang, J. S., Chen, W. H., Liu, P. H., Huang, T. T., Hsiao, J. R. & Ho, C. L., 2015 十二月 1, 於 : Journal of Mechanics in Medicine and Biology. 15, 6, 1540040.
  38. Sprouty2 protein is downregulated in human squamous cell carcinoma of the head and neck and suppresses cell proliferation in vitroLin, C. L., Chiang, W. F., Tung, C. L., Hsieh, J. L., Hsiao, J. R., Huang, W. T., Feng, L. Y., Chang, C. H., Liu, S. Y., Tsao, C. J. & Feng, Y. H., 2015 一月 1, 於 : Molecular Medicine Reports. 11, 1, p. 547-554 8 p.
  39. Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductaseChang, Y., Lan, Y. Y., Hsiao, J. R. & Chang, N. S., 2015 三月 25, 於 : Experimental Biology and Medicine. 240, 3, p. 329-337 9 p.
  40. Comparison of concurrent chemoradiotherapy versus neoadjuvant chemotherapy followed by radiation in patients with advanced nasopharyngeal carcinoma in endemic area: Experience of 128 consecutive cases with 5 year follow-upWu, S. Y., Wu, Y. H., Yang, M. W., Hsueh, W. T., Hsiao, J. R., Tsai, S. T., Chang, K. Y., Chang, J. S. & Yen, C. J., 2014 一月 1, 於 : BMC cancer. 14, 1, 787.
  41. Downregulated miR329 and miR410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7bShiah, S. G., Hsiao, J. R., Chang, W. M., Chen, Y. W., Jin, Y. T., Wong, T. Y., Huang, J. S., Tsai, S. T., Hsu, Y. M., Chou, S. T., Yen, Y. C., Jiang, S. S., Shieh, Y. S., Chang, I. S., Hsiao, M. & Chang, J. Y., 2014 十二月 15, 於 : Cancer Research. 74, 24, p. 7560-7572 13 p.
  42. Reciprocal regulation of MicroRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cellsYen, Y. C., Shiah, S. G., Chu, H. C., Hsu, Y. M., Hsiao, J. R., Chang, J. Y., Hung, W. C., Liao, C. T., Cheng, A. J., Lu, Y. C. & Chen, Y. W., 2014 一月 10, 於 : Molecular cancer. 13, 1, 6.
  43. Tea consumption and risk of head and neck cancerHuang, C. C., Lee, W. T., Tsai, S. T., Ou, C. Y., Lo, H. I., Wong, T. Y., Fang, S. Y., Chen, K. C., Huang, J. S., Wu, J. L., Yen, C. J., Hsueh, W. T., Wu, Y. H., Yang, M. W., Lin, F. C., Chang, J. Y., Chang, K. Y., Wu, S. Y., Hsiao, J. R., Lin, C. L. 及其他4, , 2014 五月 5, 於 : PloS one. 9, 5, e96507.
  44. The interplay between alcohol consumption, oral hygiene, ALDH2and ADH1B in the risk of head and neck cancerTsai, S. T., Wong, T. Y., Ou, C. Y., Fang, S. Y., Chen, K. C., Hsiao, J. R., Huang, C. C., Lee, W. T., Lo, H. I., Huang, J. S., Wu, J. L., Yen, C. J., Hsueh, W. T., Wu, Y. H., Yang, M. W., Lin, F. C., Chang, J. Y., Chang, K. Y., Wu, S. Y., Liao, H. C. 及其他5, , 2014 十一月 15, 於 : International Journal of Cancer. 135, 10, p. 2424-2436 13 p.