成大醫學院內科
歐弘毅 副教授

Dr. Horng-Yih Ou

通訊地址： 704 台南市北區勝利路138號 成大醫院內科部
連絡電話： (06)2353535 #5392(研究室) #3738(實驗室)
E-mail： wahoryi@mail.ncku.edu.tw

學歷
台北醫學大學醫學系 醫學士(1988 ~ 1995)
國立成功大學臨床醫學研究所 博士 (2004/09~ 2011/4)

經歷
現職：
國立成功大學醫學系內科學科 副教授(2013/8迄今)
成大醫院內科部內分泌新陳代謝科 主任(2015/8 迄今)
成大醫院糖尿病防治中心 主任(2017迄今)
經歷：
成大醫院內科部內分泌新陳代謝科 主治醫師(2002 迄今)
國立成功大學醫學系內科學科 臨床助理教授(2007~2012)
成大醫院內科部內分泌新陳代謝科 總醫師及臨床研究員(2000 ~2002)
成大醫院內科部 住院醫師(1997 ~2000)

專長領域
● 糖尿病學
● 肥胖醫學
● 內分泌學
● 轉譯醫學

研究主題與興趣
● 脂肪細胞激素與肝臟細胞激素與糖尿病、代謝症候群之相關性及分子機轉之研究
● 異位性脂肪研究

研究方向
糖尿病及其相關代謝症候群等疾病在台灣與先進國家所造成的健康與經濟衝擊， 是相當重要的健康議題。本人過去的研究，聚焦在異位性脂肪與肝臟及脂肪細胞 激素在胰島素阻抗性致病機轉之探討，也特別著重以代謝轉譯醫學研究方法切入 來解決問題。由臨床工作建立之檢體資料庫分析觀察，提出問題與假說，並設計 動物與細胞之基礎醫學研究方法進行機轉之探索，另一方面，也由基礎醫學研究 發現找尋其臨床意義與應用。未來，將繼續探究胰島素標的器官與組織間的交互 作用與機轉，期望能成為開發新一代糖尿病藥物的基礎，進一步提升控糖成效並 減少糖尿病併發症。

Publications:

  1. Yang YJ, Wu CT, Ou HY, Lin CH, Cheng HC, Chang WL, Chen WY, Yang HB, Lu CC, Sheu BS. Male non-insulin users with type 2 diabetes mellitus are predisposed to gastric corpus-predominant inflammation after H. pylori infection. J Biomed Sci. 2017;24:82. (SCI)

  2. Ou HY, Wu HT, Lin CH, Du YF, Hu CY, Hung HC, Wu P, Li HY, Wang SH, Chang CJ. The hepatic protection effects of hepassocin in hyperglycemic crisis. J Clin Endocrinol Metab. 2017 July; 102 (7): 2407-2415. (Corresponding author)(SCI)

  3. Yang YJ, Wu CT, Ou HY, Lin CH, Cheng HC, Chang WL, Chen WY, Yang HB, Lu CC, Sheu BS. Ten days of levofloxacin-containing concomitant therapy can achieve effective H. pylori eradication in patients with type 2 diabetes. Ann Med. 2017 Mar 7:1-8. doi: 10.1080/07853890.2017.1294761. [Epub ahead of print]

  4. Lin CH, Lee SY, Zhang CC, Du YF, Hung HC, Wu HT, Ou HY. Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator activated receptor gamma pathway. Drug Des Devel Ther. 2016; 10; 3591-3597. (Corresponding author)

  5. Karnchanasorn R, Ou HY*, Lin J, Chuang LM, Chiu KC. Viral Hepatitis and Diabetes: Clinical Implications of Diabetes Prevention Through Hepatitis Vaccination. Curr Diab Rep. 2016 Oct;16(10):101. (*equal contribution to 1st author)

  6. Wu HT, Ou HY*, Hung HC, Su YC, Lu FH, Wu JS, Yang YC, Wu CL, Chang CJ. A novel hepatokine， HFREP1， plays a crucial role in the development of insulin resistance and type 2 diabetes. Diabetologia. 2016; 59:1732-1742. (*equal contribution to 1st author)

  7. Karnchanasorn R, Huang J, Ou HY, Feng W, Chuang L-M, Chiu KC, Samoa R. Comparison of the Current Diagnostic Criterion of HbA1c with Fasting and 2-Hour Plasma Glucose Concentration. J Diabetes Res. 2016; 2016: 6195494.

  8. Lin J, Ou HY, Chuang LM, Chiu KC. Diabetes prevention through prevention of hepatitis B. Hepatology. 2016 Sep;64(3):987-8..

  9. Karnchanasorn R, Ou H-Y, Chiu KC:. Proposed guidelines for future vitamin D studies. JAMA Internal Medicine. 2016 Feb 1;176(2):280-1 doi: 10.1001/jamainternmed.2015.7974. PMID: 26830241.

  10. Hung HC, Lu FH, Wu HT, Ou HY, Yang YC, Wu JS, Chang CJ. Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals. Sci Rep. 2015 Dec 1;5:17438.

  11. Su YC, Ou HY*, Wu HT, Wu P, Chen YC, Su BH, Shiau AL, Chang CJ, Wu CL. Prothymosin α Overexpression Contributes to the Development of Insulin Resistance. J Clin Endocrinol Metab. 2015 Nov;100(11):4114-23. (*equal contribution to 1st author)(SCI)

  12. Huang J, Karnchanasorn R, Ou HY, Feng W, Chuang LM, Chiu KC, Samoa R. Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis. World J Exp Med. 2015 Nov 20;5(4):232-243. eCollection 2015 Nov 20. PubMed PMID: 26618110.

  13. Ou HY, Karnchanasorn R, Chuang LM, Chiu KC. Comment on Erondu et al. Diabetic Ketoacidosis and Related Events in the Canagliflozin Type 2 Diabetes Clinical Program. Diabetes Care. 2015 Nov;38(11):e19. 8. doi: 10.2337/dc15-1700..

  14. Huang J, Karnchanasorn R, Ou H-Y, Feng W, Chuang L-M, Chiu KC, Samoa R. Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis. World J Exp Med. 2015; 5(4): 232-243.

  15. Huang J, Ou HY*, Lin J, Karnchanasorn R, Feng W, Samoa R, Chung LM, Chiu KC. The Impact of Hepatitis B Vaccination Status on the Risk of Diabetes, Implicating Diabetes Risk Reduction by Successful vaccination. PLoS One. 2015 Oct 28;10(10):e0139730. (*equal contribution to 1st author)(SCI)

  16. Ou HY, Lu FH, Wu HT, Hung HC, Wu JS, Yang YC, Chang CJ. Both diabetes and fetuin-A are independently associated with increased risk of arterial stiffness. Clin Chim Acta. 2015; 445:133-138. (SCI)

  17. Chao WC, Yen CL, Wu YH, Chen SY, Hsieh CY, Chang TC, Ou HY, Shieh CC. Increased resistin may suppress reactive oxygen species production and inflammasomes activation in type 2 diabetic patients with pulmonary tuberculosis infection. Microbes Infect. 2015 ;17(3):195-204. (SCI)

  18. Ou HY, Wu HT, Lu FH, Su YC, Hung HC, Wu JS, Yang YC, Wu CL, Chang CJ. Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway. J Mol Endocrinol. 2014 Oct;53(2):165-74. doi: 10.1530/JME-14-0003. (SCI)

  19. Du YF, Ou HY, Beverly EA, Chiu CJ. Achieving glycemic control in elderly patients with type 2 diabetes: a critical comparison of current options. Clin Interv Aging. 2014 Nov 18;9:1963-1980. eCollection 2014.(SCI)

  20. Huang J, Ou HY, Karnchanasorn R, Chiu KC. Clinical implication of vitamin D threshold. Am J Clin Nutr. 2014;100(1):295-296. PMID: 24951577. (SCI)

  21. Huang J, Ou HY, Karnchanasorn R, Samoa R, Chuang LM, Chiu KC, Feng W. Clinical implication of fasting and post-challenged plasma glucose in diagnosis of diabetes mellitus. Endocrine. 2015; 48(2):511-8. (SCI)

  22. Wu HT, Lu FH, Su YC, Ou HY, Hung HC, Wu JS, Yang YC, Chang CJ. In vivo and in vitro anti-tumor effects of fungal extracts. Molecules. 2014;19:2546-56. (SCI)

  23. Hung HC, Lu FH, Ou HY, Wu HT, Wu JS, Yang YC, Chang CJ. Cardiotrophin-1 is associated with increased risk of arterial stiffness. Biomark Med. 2015 Feb; 9(2):123-30. doi: 10.2217/bmm.14.87.

  24. Hung HC, Lu FH, Ou HY, Wu JS, Yang YC, Chang CJ. Menopause is associated with self-reported poor sleep quality in women without vasomotor symptoms. Menopause. 2014 Aug; 21(8):834-9.

  25. Hung HC, Lu FH, Ou HY, Wu HT, Wu JS, Yang YC, Chang CJ. Increased cardiotrophin-1 in subjects with impaired glucose tolerance and newly diagnosed diabetes. Int J Cardiol. 2013 Nov 5;169(3):e33-4.

  26. Huang J, Ou HY, Chiu KC. Calcium supplements and fracture prevention. N Engl J Med. 2014;370(4):387. PMID: 24450912. (SCI)

  27. Chao TH, Tseng SY, Chen IC, Tsai YS, Huang YY, Liu PY, Ou HY, Li YH, Wu HL, Cho CL, Tsai LM, Chen JH. Cilostazol enhances mobilization and proliferation of endothelial progenitor cells and collateral formation by modifying vasculo-angiogenic biomarkers in peripheral arterial disease. Int J Cardiol. 2014;172:e371-4. (SCI)

  28. Wang CY, Ou HY*, Chen MF, Chang TC, Chang CJ. Enigmatic Ectopic Fat: Prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. J Am Heart Assoc. 2014 Feb 26;3(1):e000297. doi: 10.1161/JAHA.113.000297. (*equal contribution to 1st author). (SCI)

  29. Ou H-Y, Huang J, Samoa R, Feng W, Chuang L-M, Chiu KC. Primary effect of exercise: beta cell function versus insulin sensitivity. Ref.: Thomas P. J. etal. Pancreatic β-cell Function Is a Stronger Predictor of Changes in Glycemic Control After an Aerobic Exercise Intervention Than Insulin Sensitivity. J Clin Endocr Metab. 2013 98: 4176-4186; doi:10.1210/jc.2013-2232. (SCI)

  30. Ou HY, Thamcharoen N, Samoa R, Feng W, Chiu KC. Maximal suppression of PTH by 25(OH)D. Ref: Shapses SA et al. The Effect of Obesity on the Relationship Between Serum Parathyroid Hormone and 25-Hydroxyvitamin D in Women. JCEM. 2013 98: E886-E890; doi:10.1210/jc.2012-3369. (SCI)

  31. Hung HC, Lu FH, Ou HY, Wu HT, Wu JS, Yang YC, Chang CJ. Increased cardiotrophin-1 in subjects with impaired glucose tolerance and newly diagnosed diabetes. Int J Cardiol. 2013 Nov 5;169(3):e33-4.

  32. Wu HT, Lu FH, Ou HY, Su YC, Hung HC, Wu JS, Yang YC, Wu CL, Chang CJ. The role of Hepassocin in the development of nonalcoholic fatty liver disease. J Hepatol. 2013 Nov;59(5):1065-72. (SCI)

  33. Ou HY, Wang CY, Yang YC, Chen MF, Chang CJ. The association between nonalcoholic fatty pancreas disease and diabetes. PLoS One. 2013; 8(5): e62561. (SCI)

  34. Ou HY, Wu HT, Hung HC, Yang YC, Wu JS, Chang CJ. Multiple mechanisms of GW9508， a selective G protein-coupled receptor 40 agonist， in the regulation of glucose homeostasis and insulin sensitivity. Am J Physiol Endocrinol Metab. 2013; 304:E668-E676. (SCI)

  35. Hung HC, Yang YC, Ou HY, Wu JS, Lu FH, Chang CJ. The association between self-reported sleep quality and metabolic syndrome. PLoS One. 2013; 8: e54304. (SCI)

  36. Ou HY, Yang YC, Wu HT, Wu JS, Cheng JT, Chang CJ. Increased fetuin-A concentrations in impaired glucose tolerance with or without nonalcoholic fatty liver disease， but not impaired fasting glucose. J Clin Endocr Metab. 2012; 97:4717-4723. (SCI)

  37. Chang JW, Ou HY, Chen HL, Su HJ, Lee CC. Hyperuricemia after exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans near a highly contaminated area. Epidemiology. 2013; 24:582-589. (SCI)

  38. Ou HY, Wu HT, Hung HC, Yang YC, Wu JS, Chang CJ. Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance. Endocrinology. 2012;153(7):2974-84. (SCI)

  39. Karnchanasorn R, *Ou HY, Chiu KC. Plasma 25-hydroxyvitamin D levels are favorably associated with beta cell function. Pancreas. 2012;41(6):863-8. (Equal contribution to 1st author). (SCI)

  40. Hung HC, Yang YC, Ou HY, Wu JS, Lu FH, Chang CJ. The relationship between impaired fasting glucose and self-reported sleep quality in a Chinese population. Clin Endocrinol (Oxf). 2013; 78(4):518-524. (SCI)

  41. Karnchanasorn R, Ou HY, Chuang LM, Chiu KC. Insulin resistance is not necessarily an essential element of metabolic syndrome. Endocrine. 2013;43(1):92-9. (SCI)

  42. Ou HY, Wu HT, Yang YC, Wu JS, Cheng JT, Chang CJ. Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats. Horm Metab Res. 2011; 43(5):312-8. (SCI)

  43. Ou HY, Yang YC, Wu HT, Wu JS, Lu FH, Chang CJ. Serum fetuin-A concentrations are elevated in subjects with impaired glucose tolerance and newly-diagnosed type 2 diabetes. Clin Endocrinol (Oxf). 2011;75(4):450-455. (SCI)

  44. Ou HY, Karnchanasorn R, Lee LZ, Chiu KC. Interaction of BMI with vitamin D and insulin sensitivity. Eur J Clin Invest. 2011;41(11):1195-201. (SCI)

  45. Ken C. Chiu and Horng-Yi Ou and Rudruidee Karnchanasorn， Glucocorticoid-induced hyperglycemia. J Clin Endocrinol Metab. published online August 22， 2011.

  46. Chen PY, Wu TJ, Ou HY, Li MC, Hu SC, Huang SM. Applying intraoperative insulin level monitoring for tumor removal in a patient with recurrent pancreatic multiple insulinomas. J Formos Med Assoc. 2011;110(6):410-4. (SCI)

  47. Hao-Chang Hung, Yi-Ching Yang, Horng-Yih Ou, Jin-Shang Wu, Feng-Hwa Lu, Chih-Jen Chang. The Association between impaired glucose tolerance and self-reported sleep quality in a Chinese population. Can J Diabetes. 2012; 36(3):95-99. (SCI)

  48. Hao-Chang Hung, Yi-Ching Yang, Horng-Yih Ou, Jin-Shang Wu, Feng-Hwa Lu, Chih-Jen Chang. The association between self-reported sleep quality and overweight in a Chinese population. Obesity (Silver Spring). 2012 Jun 22. doi: 10.1038/oby.2012.169. [Epub ahead of print] (SCI)

  49. Chang JW, Ou HY, Chen HL, Guo HR, Liao PC, Lee CC. Interrelationship between exposure to PCDD/Fs and hypertension in metabolic syndrome in Taiwanese living near a highly contaminated area. Chemosphere. 2010; 81:1027-32. (SCI)

  50. Liang YL, Huang SM, Peng SL, Hsiao SH, Hung HC, Ou HY, Wu TJ. Amiodarone-induced thyrotoxicosis in a patient with autonomously functioning nodular goiter. Ann Pharmacother. 2009; 43:134-8. (SCI)

  51. Yu BC, Chang CK, Ou HY, Cheng KC, Cheng JT. Decrease of peroxisome proliferator-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats. Cardiovasc Res. 2008; 80:78-87. (SCI)

  52. Huang CW, Tsai JJ, Ou HY, Wang ST, Cheng JT, Wu SN, Huang CC. Diabetic hyperglycemia is associated with the severity of epileptic seizures in adults. Epilepsy Res. 2008; 79:71-7. (SCI)

  53. Hung HC, Ou HY, Huang JS, Chuang MC, Wu TJ. Tumor-associated hypercalcemia in a patient with Paget's disease. Kaohsiung J Med Sci. 2008; 24:152-156. (SCI)

  54. Wu TJ, Ou HY, Chou CW, Hsiao SH, Lin CY, Kao PC. Decrease in inflammatory cardiovascular risk markers in diabetic patients with hyperlipidemia treated with fenofibrate. Ann Clin Lab Sci. 2007; 37:158-66. (SCI)

  55. Hao-Chang Hung, Ming-Che Chuang, Horng-Yih Ou, Ta-Jen Wu. The characteristics of patients with autoimmune polyendocrine syndrome in a medical center in southern Taiwan. Endocrinology & Diabetology. 2007; 20:42-50.

  56. Shu-Hwa Hsiao, Horng-Yih Ou, Ta-Jen Wu. Clinical evidence of GLP-1 receptor agonists and DPP IV inhibitors in the treatment of type 2 diabetes. J Intern Med Taiwan. 2007; 18:189-194.

  57. Hao-Chang Hung, Ming-Che Chuang, Horng-Yih Ou, Shu-Hwa Hsiao, Ta-Jen Wu. Recent advance in anti-osteoporotic therapy. J Intern Med Taiwan. 2007; 18:313-321.

  58. Hsiang-Yi Tsai, Yen-Kuang Yang, Eugene Hsin Yu, Horng-Yih Ou. Anxiety and Depression Symptoms in Patients with Thyroid Cancer Isolated for 131I Treatment. Taiwanese J Psychiatry. 2007;21:299-303.

  59. Bi-Fang Lee, Ta-Jen Wu, Horng-Yih Ou, Nan-Tsing Chiu. Thyroid Imaging in a Patient with Thyrotoxicosis Factitia. Ann Nucl Med Sci. 2007;20:235-238.

  60. Hao-Chang Hung, Horng-Yih Ou, Shu-Hwa Hsiao, Ta-Jen Wu. Anti-obesity agents: an update. J Intern Med Taiwan. 2006; 17:155-162.

  61. Ou HY, Cheng JT, Yu EH, Wu TJ. Metformin increases insulin sensitivity and plasma beta-endorphin in human subjects. Horm Metab Res. 2006; 38:106-111. (SCI)

  62. Chou YY, Ou HY, Wu TJ, Tsai SC, Lin SJ, Yu EH. Hypophosphatasia in Taiwan: report of two cases. Kaohsiung J Med Sci. 2005; 21:134-7. (SCI)

  63. Horng-Yih Ou, Eugene Hsin Yu, Shu-Hwa Hsiao, Chia-Yih Lin, Ta-Jen Wu. Fenofibrate has beneficial effects on lipid profile but no effect on glucose metabolism in type 2 diabetic patients with hyperlipidemia: a randomized， double-blinded， placebo-controlled trial. Int J Endocrinol Metab. 2005; 4:184-192.

  64. Horng-Yih Ou, Shu-Hwa Hsiao, Eugene Hsin Yu, Ta-Jen Wu. Etiologies and clinical manifestations of hyperprolactinemia in a medical center in southern Taiwan. J Intern Med Taiwan. 2004; 15:19-24.

  65. Chung YH, Ou HY, Wu TJ. Development of hyperthyroidism following primary hypothyroidism: a case report. Kaohsiung J Med Sci. 2004; 20:188-91. (SCI)

  66. Chiung-Mei Weng, Eugene Hsin Yu, Horng-Yih Ou, and Ta-Jen Wu. Incretin Hormone Has Potential to Become An Antidiabetic Therapy. J Intern Med Taiwan. 2004; 15: 199-207.

  67. Horng-Yih Ou, Yung-Chiang Ma, Eugene Hsin Yu, Ta-Jen Wu. Hypothyroidism-related hyperprolactinemia—report of two cases and literature review. TZU CHI Medical Journal. 2003; 15:417-20.

  68. Ou HY, Hung CJ, Hsu WH, Yu EH, Wu TJ. Variability of clinical presentations in three cases of parathyroid carcinoma. J Formos Med Assoc. 2003; 102:266-9. (SCI)

  69. 杜業豐,歐弘毅,吳達仁,黃士銘. (Ye-Fong Du， Horng-Yih Ou， Ta-Jen Wu， and Shih-Ming Huang). 非胰島素瘤胰原性低血糖症候群 (Noninsulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS). 內科學誌 (J Intern Med Taiwan). 2013：24：181-188.

  70. 林穎正,吳達仁,歐弘毅. (Ying-Cheng Lin， Ta-Jen Wu， and Horng-Yih Ou). 果糖與代謝症候 (Fructose and Metabolic Syndrome). 內科學誌 (J Intern Med Taiwan). 2014：25：410-416.