國立成功大學附設醫院 內科
林建中 副教授

Professor Chien-Chung Lin

連絡電話： (06)2353535 #2589 (研究室) #3120 (實驗室)
E-mail： n032989@mail.hosp.ncku.edu.tw
joshcclin@gmail.com
chausus@ms31.hinet.net

學歷
UCLA visiting scholar (2013)
成功大學臨醫所博士 (2011)

研究方向
● 非侵襲性之基因檢測
● 細胞外吐小體（exosome）在調控腫瘤血管新生角色
● 腫瘤微環境中細胞外吐小體在肺癌抗藥機轉之角色

研究興趣
● 探討並建立以非侵襲性（血液及唾液）之檢測方式檢驗肺癌之基因突變
● 探討exosome在腫瘤微環境中如何促進血管新生作用及造成對肺癌治療之抗藥性

Publications:

  1. Yang SC, Lin CC, Lai WW, Chang SM, Hwang JS, Su WC, Wang JD. Dynamic changes in quality of life after three first-line therapies for EGFR mutation-positive advanced non-small-cell lung cancer. Ther Adv Med Oncol. 2018 Feb 5;10:1758834018755072.

  2. Chang WY, Wu YL, Su PL, Yang SC, Lin CC, Su WC. The impact of EGFR mutations on the incidence and survival of stages I to III NSCLC patients with subsequent brain metastasis. PLoS One. 2018 Feb 15;13(2):e0192161. doi: 10.1371(corresponding author).

  3. Sivashanmugan K, Huang WL, Lin CH, Liao JD, Lin CC, Su WC, Wen TC. Bimetallic nanoplasmonic gap-mode SERS substrate for lung normal and cancer-derived exosomes detection. J Taiwan Inst Chem Eng 2017 Nov;80:149–155.

  4. Yang SC, Lai WW, Lin CC, Su WC, Ku LJ, Hwang JS, Wang JD Cost-effectiveness of implementing computed tomography screening for lung cancer in Taiwan. Lung Cancer. 2017 Jun;108:183-191

  5. Huang WL, Chen YL, Yang SC, Ho CL, Wei F, Wong DT, Su WC, Lin CC. Liquid biopsy genotyping in lung cancer: ready for clinical utility? Oncotarget. 2017 Mar 14;8(11):18590-18608(corresponding author).

  6. Seow WJ, Matsuo K, Lin CC, Rothman N, Kohno T, Chanock SJ, Lan Q. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet. 2017 Jan 15;26(2):454-465.

  7. Wang Z, Seow WJ, Lin CC, Rothman N, Lan Q. Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Hum Mol Genet. 2016 Feb 1;25(3):620-9.

  8. Zhang Y, Sun J, Lin CC, Abemayor E, Wang MB, Wong DT. The emerging landscape of salivary diagnostics. Periodontol 2000. 2016 Feb;70(1):38-52(co-author).

  9. Huang WL, Wei F, Wong DT, Lin CC, Su WC. The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer. Biomed Res Int. 2015;2015:340732 (corresponding author).

  10. Lin CC, Huang WL, Wei F, Su WC, Wong DT. Emerging platforms using liquid biopsy to detect EGFR mutations in lung cancer. Expert Rev Mol Diagn. 2015;15(11):1427-40.

  11. Sampson JN, Wheeler WA, Yeager M, Lin CC, Silverman DT, Slager SL, Chanock SJ, Chatterjee N. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types. J Natl Cancer Inst. 2015 Oct 12;107(12):djv279.

  12. Machiela MJ, Hsiung CA, Shu XO, Lin CC, Chanock SJ, Rothman N, Lan Q. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia. Int J Cancer. 2015 Jul 15;137(2):311-9.

  13. Wei F1, Lin CC, Joon A, Feng Z, Troche G, Lira ME, Chia D, Mao M, Ho CL, Su WC, Wong DT. Non-Invasive Saliva-Based EGFR Gene Mutation Detection in Lung Cancer Patients Am J Respir Crit Care Med. 2014 Nov 15;190(10):1117-26. (co-author ,Featured cover article)

Conference poste:

  1. Chien-Chung Lin, Wei-Lun Huang and Wu-Chou Su Extracellular vesicles derived from lung cancer cell may contribute to the formation of malignant pleural effusion via activating Stat3/Tissue factor/VEGF AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC

  2. Chien-Chung Lin, Wei-Lun Huang and Wu-Chou Su Lung cancer cell derived extracellular vesicles carrying DNAs, RNAs and proteins that may trigger oncogenic signals and promote angiogenesis AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA