國立成功大學醫學院生化所

教授兼所長

鄭宏祺 博士

Dr. H.C. Cheng

English Main Page

研究專長

研究方向及興趣

  1. 已知癌症轉移所需之粘著分子(Adhesion molecules)方面的研究。

  2. 尋找尚未被發現的臟器特異的粘著分子—大腸直腸癌，肝癌，鼻咽癌等。

  3. 設法阻斷癌症細胞(fibronectin)及內皮細胞(dipeptidyl peptidase IV [DPP IV])之間的粘著反應，使得轉移無從發生，如：
    1. 阻斷粘著受器/配合基間的結合處。
    2. 阻斷癌症細胞及內皮細胞內的訊息傳導。
    3. 癌症疫苗。

  4. 繼續探討由癌症細胞/內皮細胞粘著所刺激導致的後粘著反應(post-adhesion events),如：
    1. 癌症細胞的血管外滲(extravasation)，金屬蛋白酶 metalloprotease 的分泌，細胞移動(migration)或增生(proliferation)。
    2. 內皮細胞的縮進(retraction)，凋零(apoptosis)或血管生成(angiogenesis)。
    3. 與細胞外間質(extracellular matrix)或炎症細胞間的相互反應；
  1. CD26 (DPP IV) 在癌症免疫學及免疫治療上之重要性與應用。

Selected Publications:

  1. Wang YT, Chen J, Chang CW, Jen J, Huang TY, Chen CM, Shen R, Liang SY, Cheng IC, Yang SC, Lai WW, Cheng KH, Hsieh TS, Lai MZ, Cheng HC, Wang YC, Chen RH. Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment. J Clin Invest. 2017;127(8):2982-2997.
  2. Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW, Wang YC. Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis. Clin Cancer Res. 2017;23(9):2335-2345.
  3. Wang YJ, Lin JF, Cheng LH, Chang WT, Kao YH, Chang MM, Wang BJ, Cheng HC*. Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis. J Hematol Oncol. 2017;10(1):72. (*Corresponding author)
  4. Tseng RC, Chang JW, Mao JS, Tsai CD, Wu PC, Lin CJ, Lu YL, Liao SY, Cheng HC, Hsu HS, Wang YC. Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer. Oncotarget. 2015;6(42):44207-21.
  5. Cheng HC*, Chang MM, Tseng YL. The dual role of fibronectin in lung cancer progression. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl): Abstract nr 2274. (*Corresponding author)
  6. Chang YH, Chiu YJ, Cheng HC, Liu FJ, Lai WW, Chang HJ, Liao PC. Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma. Tumour Biol. 2015;36(5):3957-67.
  7. Huang CL, Chiu WT, Lo YL, Chuang CH, Chen YB, Chang SJ, Ke TT, Cheng HC, Wu HL. Optical detection of metastatic cancer cells using a scanned laser pico-projection system. Laser Phys Lett. 2015; 12: 035602.
  8. Hsu JY, Chang KY, Chen SH, Lee CT, Chang ST, Cheng HC, Chang WC, Chen BK. Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. Oncotarget. 2015;6(3):1723-39.
  9. Tsai CH, Cheng HC, Wang YS, Lin P, Jen J, Kuo IY, Chang YH, Liao PC, Chen RH, Yuan WC, Hsu HS, Yang MH, Hsu MT, Wu CY, Wang YC. Small GTPase Rab37 targets tissue inhibitor of etalloproteinase 1 for exocytosis and thus suppresses tumor metastasis. Nat Commun. 2014;5:4804.
  10. Shieh JM, Shen CJ, Chang WC, Cheng HC, Chan YY, Huang WC, Chang WC, Chen BK. An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeuticdrug-induced cancer cell death. PLoS One. 2014;9(6):e99242.
  11. Ke CS, Liu HS, Yen CH, Huang GC, Cheng HC, Huang CY, Su CL. Curcumin-induced Aurora-A suppression not only causes itotic defect and cell cycle arrest but also alters chemosensitivity to anticancer drugs. J Nutr Biochem. 2014;25(5):526-39.
  12. Kuo YZ, Tai YH, Lo HI, Chen YL, Cheng HC, Fang WY, Lin SH, Yang CL, Tsai ST, Wu LW. MiR-99a exerts anti-metastasis through inhibiting myotubularin-related protein 3 expression in oral cancer. OraL Dis. 2014;20(3):e65-75.
  13. Wu CI, Chang MM, Su CL, Ling P, Chang WT, Cheng HC*. Impacts of protease inhibitors on clathrin and fibronectin in cancer metastasis. Biomarkers and Genomic Medicine, 2014;6(1):23-31. (*Corresponding author)
  14. Hsing CH, Kwok FA, Cheng HC, Li CF, Chang MS. Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression. PLoS One. 2013;8(10):e75254.
  15. Hsiao YW, Li CF, Chi JY, Tseng JT, Chang Y, Hsu LJ, Lee CH, Chang TH, Wang SM, Wang DD, Cheng HC, Wang JM. CCAAT/enhancer binding protein δ in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma. Sci Signal. 2013;6(284):ra59.
  16. Weng TY, Chiu WT, Liu HS, Cheng HC, Shen MR, Mount DB, Chou CY. Glycosylation regulates the function and membrane localization of KCC4. Biochim Biophys Acta. 2013;1833(5):1133-46.
  17. Hsing CH, Cheng HC, Hsu YH, Chan CH, Yeh CH, Li CF, Chang MS. Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome. Clin Cancer Res. 2012;18(3):713-25.
  18. Chang YH, Lee SH, Liao IC, Huang SH, Cheng HC*, Liao* PC. Secretomic analysis identifies alpha-1 antitrypsin (A1AT) as a required protein in cancer cell migration, invasion, and pericellular fibronectin assembly for facilitating lung colonization of lung adenocarcinoma cells. Mol Cell Proteomics. 2012;11(11):1320-39. (*Co-corresponding author)
  19. Lo FY, Chen HT, Cheng HC, Hsu HS, Wang YC. Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer. Lung Cancer. 2012;77(3):585-92.
  20. Shieh JM, Wei TT, Tang YA, Huang SM, Wen WL, Chen MY, Cheng HC, Salunke SB, Chen CS, Lin P, Chen CT, Wang YC. Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models. PLoS One. 2012;7(1):e30240.
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Updated: 2017.11.16