國立成功大學醫學院生化所

副教授

張文粲 博士

Prof. WT Chang

English Main Page

研究專長

研究方向

研究興趣

Selected Publications:

  1. Hu KH, Chen CW, Tseng PL, Cheng HC, Lin YH, Tsai WH, Cheng TJ, Wu WH, Yeh CW, Lin CC, Tsai HJ, Chang HC, Chuang JH, Shan YS, Chang WT. The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition. Oncotarget, (In press). 2018

  2. Tseng PL, Wu WH, Hu TH, Chen CW, Cheng HC, Li CF, Tsai WH, Tsai HJ, Hsieh MC, Chuang JH, Chang WT. Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect. Scientific Reports, 8, 3081. 2018

  3. Lin TC, Liao YC, Chang WT, Yang CH, Cheng LH, Cheng M, Cheng HC. The establishment of a lung colonization assay for circulating tumor cell visualization in lung tissues. JoVE, (In press). 2018

  4. Chen RJ, Kuo HC, Cheng LH, Lee YH, Chang WT, Wang BJ, Wang YJ, Cheng HC. Apoptotic and nonapoptotic activities of pterostilbene against cancer. International Journal of Molecular Sciences, 19, E287. 2018

  5. Chen CW, Cheng TJ, Ho CH, Wang JJ, Weng SF, Hou YC, Cheng HC, Chio CC, Shan YS, Chang WT. Increased risk of brain cancer incidence in stroke patients: A clinical case series, population-based and longitudinal follow-up study. Oncotarget, 8, 108989-108999. 2017

  6. Wang YJ, Lin JF, Cheng LH, Chang WT, Kao YH, Chang MM, Wang BJ, Cheng HC. Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis. Journal of Hematology & Oncology, 10, 72. 2017

  7. Kuo WS, Chang CY, Chen HH, Hsu CL, Wang JY, Kao HF, Chou LC, Chen YC, Chen SJ, Chang WT, Tseng SW, Wu PC, Pu YC. Two-photon photoexcited photodynamic therapy and contrast agent with antimicrobial graphene quantum dot. ACS Applied Materials & Interfaces, 8, 30467-30474. 2016

  8. Kuo WS, Hsu CL, Chen HH, Chang CY, Kao HF, Chou LC, Chen YC, Chen SJ, Chang WT, Tseng SW, Wang JY, Pu YC. Graphene quantum dots conjugated with polymers for two-photon properties under two-photon excitation. Nanoscale, 8, 16874-15880. 2016

  9. Chang YJ, Chen YJ, Huang CW, Fan SC, Huang BM, Chang WT, Tsai YS, Su FC, Wu CC. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation. Frontiers in Bioengineering and Biotechnology, 4, 27. 2016

  10. Chen CW, Wu EH, Huang J, Chang WT, Ao KH, Cheng TJ, Yang WY. Dynamic evolution of D-dimer in cerebrospinal fluid predicts poor outcome in patients with spontaneous intracerebral hemorrhage combined with intraventricular hemorrhage. Journal of clinical neuroscience, 29, 149-154. 2016

  11. Chen CW, Puvanesarajah V, Lo SL, Wu EH, Chang WT, Chio CC, Cheng TJ. Surgical site infection following spine surgery: diagnostic potential of CRP, ESR, and WBC in predicting infection. Emergency Medicine (Los Angel), 5, 277. 2015

  12. Chang WT, Chen SJ, Chang CY, Liu YH, Chen CH, Yang CH, Chou LC, Chang JC, Cheng LC, Kuo WS, Wang JY. Effect of size-dependence photodestructive efficacy by gold nanomaterials with multiphoton laser. ACS Applied Materials & Interfaces, 7, 17318-17329. 2015

  13. Tsai WH, Hwang YS, Hung TY, Weng SF, Lin SJ, Chang WT. Association between mechanical ventilation and neurodevelopmental disorders in a nationwide cohort of extremely low birth weight infants. Research in Developmental Disabilities, 35, 1544-1550. 2014

  14. Wu CI, Chang MM, Su CL, Ling P, Chang WT and Cheng HC. Impacts of protease inhibitors on clathrin and fibronectin in cancer metastasis. Biomarkers and Genomic Medicine, 6, 23-31. 2014

  15. Tsai WH and Chang WT. Construction of simple and efficient siRNA validation systems for screening and identification of effective RNAi-targeted sequences from mammalian genes. Methods in Molecular Biology, 1101, 321-338. 2014

  16. Yeh HH, Chang WT, Lu KC, Lai WW, Liu HS, and Su WC. Upregulation of tissue factor by activated Stat3 contributes to malignant pleural effusion generation via enhancing tumor metastasis and vascular permeability in lung adenocarcinoma. PLoS ONE, 8, e75287. 2013

  17. Kao HF, Chang-Chien PW, Chang WT, Yeh TM, and Wang JY. Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. International Immunophamacology, 15, 565-574. 2013

  18. Lin CC, Cheng TL, Tsai WH, Tsai HJ, Hu KH, Chang HC, Yeh CW, Chen YC, Liao CC, and Chang WT. Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy. Scientific Reports, 2, 785. 2012

  19. Chang YS, Tsai CT, Huangfu CA, Huang WY, Lei HY, Lin CF, Su IJ, Chang WT, Wu PH, Chen YT, Hung JH, Young KC, and Lai MD. ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells. Journal of Cellular Biochemistry, 112, 881-893. 2011

  20. Hsu CC, Chiang CW, Cheng HC, Chang WT, Chou CY, Tsai HW, Lee CT, Wu ZH, Lee TY, Chao A, Chow NH, Ho CL. Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach. Oncogene, 30, 654-667. 2011

  21. Huang WL, Yeh HH, Lin CC, Lai WW, Chang JY, Chang WT, Su WC. Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells. Molecular Cancer, 9, 309. 2010

  22. Hung JH, Yan CW, Su IJ, Wang HC, Lei HY, Lin WC, Chang WT, Huang W, Lu TJ, Lai MD. Hepatitis B virus surface antigen interacts with acid alpha-glucosidase and alters glycogen metabolism. Hepatology Research, 40, 633-640. 2010

  23. Cheng TL, Liao CC, Tsai WH, Lin CC, Yeh CW, Teng CF, and Chang WT. Identification and characterization of mitochondrial targeting sequence and mechanism in human citrate synthase. Journal of Cellular Biochemistry, 107, 1002-1015. 2009

  24. Cheng TL, Teng CF, Tsai WH, Yeh CW, Wu MP, Hsu HC, Hung CF, and Chang WT. Multi-target therapy of malignant cancers by the head-to-tail tandem array multiple shRNAs expression system. Cancer Gene Therapy, 16, 516-531. 2009

  25. Chen YH, Huang YH, Wu HL, Wu MP, Chang WT, Kuo YZ, Lu KC, Wu LW. Angiostatin K1-3 induces E-selectin via AP1 and Ets1: a mediator for anti-angiogenic action of K1-3. Journal of Thrombosis and Haemostasis, 6, 1953-1961. 2008

  26. Cheng YJ, Lee CH, Lin YP, Hwang JY, Su CC, Chang WT, and Yang BC. Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through ERK pathway. International Journal of Cancer, 123, 1278-1285. 2008

  27. Chen CL, Lin CF, Chang WT, Huang WC, Teng CF, and Lin YS. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood, 111, 4365-4374. 2008

  28. Chang WW, Su IJ, Lai MD, Chang WT, Huang W, Lei HY. Suppression of p38 mitogen-activated protein kinase inhibits hepatitis B virus replication in human hepatoma cell: the antiviral role of nitric oxide. Journal of Viral Hepatitis, 15, 490-497. 2008

  29. 鄭琮霖, 邱志亮, 胡耿薰, 林晋志, 葉晉瑋, 張文粲. 不容忽視的沉默---核糖核酸干擾. 科學發展月刊, 416, 48-57. 2007

  30. Cheng TL and Chang WT. Construction of simple and efficient DNA vector-based short hairpin RNA expression systems for specific gene silencing in mammalian cells. Methods in Molecular Biology, 408, 223-241. 2007

  31. Wu RH, Cheng TL, Lo SR, Hsu HC, Hung CF, Teng CF, Wu MP, Tsai WH, and Chang WT. A tightly regulated and reversibly inducible siRNA expression system for conditional RNAi-mediated gene silencing in mammalian cells. The Journal of Gene Medicine, 9, 620-634. 2007

  32. Wang YH, Chiu WT, Wang YK, Wu CC, Chen TL, Teng CF, Chang WT, Chang HC, Tang MJ. Deregulation of AP-1 protein family in collagen gel-induced epithelial cell apoptosis mediated by low substratum rigidity. The Journal of Biological Chemistry, 282, 752-763. 2007

  33. Lin CC, Tu CF, Yen MC, Chen MC, Hsieh WJ, Chang WC, Chang WT, and Lai MD. Inhibitor of heat shock protein 90 enhances the anti-tumor effect of DNA vaccine targeting clients of heat shock protein. Molecular Therapy, 15, 404-410. 2007

  34. Lu TJ, Lai WY, Huang CY, Hsieh WJ, Yu JS, Hsieh YJ, Chang WT, Leu TH, Chang WC, Chuang WJ, Tang MJ, Chen TY, Lu TL, and Lai MD. Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein tyrosine phosphatase (PTP)-PEST. The Journal of Biological Chemistry, 281, 38405-38417. 2006

  35. Hung CF, Lu KC, Cheng TL, Wu RH, Huang LY, Teng CF, and Chang WT. A novel siRNA validation system for functional screening and identification of effective RNAi probes in mammalian cells. Biochemical and Biophysical Research Communications, 346, 707-720. 2006

  36. Jean JS, Guo HR, Chen SH, Liu CC, Chang WT, Yang YJ, and Huang MC. The association between rainfall rate and occurrence of an enterovirus epidemic due to a contaminated well. Journal of Applied Microbiology, 101, 1224-1231. 2006

  37. Hung CF, Cheng TL, Wu RH, Teng CF, and Chang WT. A novel bidirectional expression system for simultaneous expression of both the protein-coding genes and short hairpin RNAs in mammalian cells. Biochemical and Biophysical Research Communications, 339, 1035-1042. 2006

  38. Tan CY, Chen YL, Wu LSH, Liu CF, Chang WT, and Wang JY. Association of CD14 promoter polymorphisms and soluble CD14 levels in mite allergen sensitization of children in Taiwan. Journal of Human Genetics, 51, 59-67. 2006

  39. Liu CF, Chen YL, Chang WT, Shieh CC, Yu CK, Reid KBM, and Wang JY. Mite allergen induces nitric oxide production in alveolar macrophage cell lines via CD14/TLR4, and is inhibited by surfactant protein-D. Clinical and Experimental Allergy, 35, 1615-1624. 2005

  40. Chang WW, Su IJ, Lai MD, Chang WT, Huang W, and Lei HY. Toll-like receptor-4 plays an anti-HBV role in a murine of acute hepatitis B virus expression. World Journal of Gastroenterology, 11, 6631-6637. 2005

  41. Cheng TL, Chang WW, Su IJ, Lai MD, Huang W, Lei HY, and Chang WT. Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference. Biochemical and Biophysical Research Communications, 336, 820-830. 2005

  42. Liu CI, Cheng TL, Chen SZ, Huang YC, and Chang WT. LrrA, a novel leucine rich repeat protein involved in cytoskeleton remodeling, is required for multicellular morphogenesis in Dictyostelium discoideum. Developmental Biology, 285, 238-251. 2005

  43. Lin CF, Chen CL, Chang WT, Jan MS, Hsu LJ, Wu RH, Fang YT, Tang MJ, Chang WC, and Lin YS. Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. The Journal of Biological Chemistry, 280, 23758-23765. 2005

  44. Wang HC, Chang WT, Chang WW, Wu HC, Huang W, Lei HY, Lai MD, Fausto N, and Su IJ. Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology, 41, 761-770. 2005

  45. Wu MT, Wu RH, Hung CF, Cheng TL, Tsai WH, and Chang WT. Simple and efficient DNA vector-based RNAi systems in mammalian cells. Biochemical and Biophysical Research Communications, 330, 53-59. 2005

  46. Tsai WH, Chang CW, Chuang WJ, Lin YS, Wu JJ, Liu CC, Chang WT, and Lin MT. SPE B-induced apoptosis in A549 cells is mediated by a receptor- and mitochondria-dependent pathway. Infection and Immunity, 72, 7055-7062. 2004

  47. Hung JH, Su IJ, Lei HY, Wang HC, Lin WC, Chang WT, Huang W, Chang WC, Chang YS, Chen CC, and Lai MD. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-κB and pp38 mitogen-activated protein kinase. The Journal of Biological Chemistry, 279, 46384-46392. 2004

  48. Lin CF, Chen CL, Chang WT, Jan MS, Hsu LJ, Wu RH, Tang MJ, Chang WC, and Lin YS. Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramide- and Etoposide-induced apoptosis. The Journal of Biological Chemistry, 279, 40755-40761. 2004

  49. Hsieh YH, Su IJ, Wang HC, Chang WW, Lei HY, Lai MD, Chang WT, and Huang W. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis, 25, 2023-2032. 2004

  50. Huang YC, Chen YH, Lo SR, Liu CI, Wang CW, and Chang WT. Disruption of the peroxisomal citrate synthase CshA affects cell growth and multicellular development in Dictyostelium discoideum. Molecular Microbiology, 53, 81-91. 2004

  51. Chang WW, Su IJ, Lai MD, Chang WT, Huang W, and Lei HY. The role of inducible nitric oxide synthase in a murine acute hepatitis B virus (HBV) infection model induced by hydrodynamics-based in vivo transfection of HBV-DNA. Journal of Hepatology, 39, 834-842. 2003

  52. Chang WT. Slime mold Dictyostelium discoideum for developmental biology study. Journal of Genetics and Molecular Biology, 12, 65-70. 2001

  53. Hsu YS, Chang WT, Newell PC, and Gross JD. A negative regulatory element in a prespore-specific promoter of Dictyostelium discoideum. Biochimica et Biophysica Acta, 1447, 67-70. 1999

  54. Guo K, Chang WT, and Newell PC. Isolation of spermidine synthase gene (spsA) of Dictyostelium discoideum. Biochimica et Biophysica Acta, 1449, 211-216. 1999

  55. Kim HJ, Chang WT, Meima M, Gross JD, and Schaap P. A novel adenylyl cyclase detected in rapidly developing mutants of Dictyostelium. The Journal of Biological Chemistry, 273, 30859-30862. 1998

  56. Anjard C, Chang WT, Gross JD, and Nellen W. Production and activity of spore differentiation factors (SDFs) in Dictyostelium. Development, 125, 4067-4075. 1998

  57. Thomason PA, Traynor D, Cavet G, Chang WT, Harwood AJ, and Kay RR. An intersection of the cAMP/PKA and two-component signal transduction systems in Dictyostelium. The EMBO Journal, 17, 2838-2845. 1998

  58. Chang WT, Thomason PA, Gross JD, and Newell PC. Evidence that the RDEA protein is a component of a multistep phosphorelay modulating rate of development in Dictyostelium. The EMBO Journal, 17, 2809-2816. 1998

  59. Chang WT, Newell PC, and Gross JD. Identification of the cell fate gene stalky in Dictyostelium. Cell, 87, 471-481. 1996

  60. Chang WT, Gross JD, and Newell PC. Trapping developmental promoters in Dictyostelium. Plasmid, 34, 175-183. 1995

  61. WU FY, Chang WT, and Sun TP. Vitamin K3 induces cell death via apoptosis in human cervical carcinoma TSGH8302 cells. Oncology Reports, 1, 53-58. 1994

  62. Chau LY, Lin TA, Chang WT, Chen CH, Shue MJ, Hsu YS, Hu CY, Tsai WH, and Sun GY. Endothelin-mediated calcium response and inositol 1, 4, 5-trisphosphate release in neuroblastoma-glioma hybrid cells (NG108-15): cross talk with ATP and bradykinin. Journal Neurochemistry, 60, 454-460. 1993

  63. Chau LY, Hu CY, Chang WT, and Hsu YS. Possible existence of two subsets of platelet-activating factor receptor to mediate polyphosphoinositide breakdown and calcium influx in neuroblastoma x glioma hybrid NG 108-15 cells. Journal Neurochemistry, 59, 1090-1098. 1992

Conference Papers:

  1. Lin YH， Chung ST， Hsieh MC， Chen CW， Tseng PL， Tsai WH， Cheng HC， Chang WT. Inhibition of RNase P activity promotes Bcl2 expression and sensitizes cancer cells to Bcl2 inhibitor. The 33th Joint Annual Conference of Biomedical Science， Taipei， March 24-25， 2018.

  2. Lin YH， Hsieh MC， Chen CW， Tseng PL， Tsai WH， Shan YS， Chuang JH， Chang WT. Loss of telomerase RNA component (TERC) specifically accelerates tumor cell migration. The 32th Joint Annual Conference of Biomedical Science， Taipei， March 25-26， 2017. (第32屆生物醫學聯合學術年會台灣生物化學及分子生物學學會優秀論文壁報獎)

  3. Lin YH， Chen YC， Hsieh MC， Chen CW， Tseng PL， Huang CW， Dai JS， Chang CC， Chang WT. Inhibited ubiquitin-activating enzyme UBE1 expression in malignant cancer cells decreases tumor malignancy and sensitizes to 2-deoxyglucose inhibition. The 31th Joint Annual Conference of Biomedical Science， Taipei， March 26-27， 2016.

  4. Chen YC， Huang CW， Chen CW， Tseng PL， Lin YH， Tsai WH， Chang WT. Attenuated the ubiquitin-mediated protein degradation in human malignant cancer cells decreases tumor malignancy and increases susceptibility to 2-deoxyglucose inhibition. The 30th Joint Annual Conference of Biomedical Science， Taipei， March 21-22， 2015.

  5. Liu CJ， Hsu HC， Huang KJ， Tsai WH， Lei HY， Chang WT. Inhibition of dengue virus infection by RNA interference-mediated gene silencing. The 29th Joint Annual Conference of Biomedical Science， Taipei， March 15-16， 2014.

  6. Li YS， Hu KH， Tsai WH， Chang HC， Wu WH， Yeh CW， Lin CC， Tsai HJ， Liu CJ Liu， Chang WT. Inhibition of the glycolytic enzyme hexokinase isozyme HK1 but not HK2 accelerates tumor malignancy via deregulation of energy metabolism. The 28th Joint Annual Conference of Biomedical Science， Taipei， March 23-24， 2013. (第28屆生物醫學聯合學術年會台灣生物化學及分子生物學學會優秀壁報論文獎)

  7. Chang HC， Tsai WH， Shi JN， Chen CY， Liu C J， Li YS， and Chang WT. Loss of lactate dehydrogenase B results in aberrant energy metabolism and accelerated malignant transformation of cancer cells. Twentieth Symposium on Recent Advances in Cellular and Molecular Biology， Kaohsiung， February 7-9， 2012.

  8. Shi JN， Tseng PL， Wu WH， Tsai WH， Tsai HJ， Wu EC， Chuang JH， and Chang WT. Succinate dehydrogenase B expression in hepatocellular carcinoma: a possible indicator for chemotherapy by 2-deocyl glucose. Nineteenth Symposium on Recent Advances in Cellular and Molecular Biology， Kaohsiung， February 10-12， 2011.

  9. Wu WH， Hu KH， Tsai WH， Cheng AJ， Yeh CW， Lin CC， Chen YT， and Chang WT. Knockdown of human hexokinase 1 but not hexokinase 2 accelerates tumor malignancy via inducing epithelial-mesenchymal transition. Eighteenth Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， January 20-22， 2010.

  10. Chen YC， Cheng TL， Teng CF， Tsai WH， Yeh CW， Wu MP， Hsu HC， Hung CF， and Chang WT. Multi-target therapy of malignant cancers by the head-to-tail tandem array multiple shRNAs expression system. Seventeenth Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， February 13-15， 2009.

  11. Lin CC， Cheng TL， Liao CC， Teng CF， Tsai WH， and Chang WT. The mitochondrial targeting mechanism of human citrate synthase. Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， January 23-25， 2008.

  12. Cheng TL， Liao CC， Yeh CW， Teng CF， and Chang WT. Knockdown of human citrate synthase by RNA interference induces epithelial-mesenchymal transition. Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， February 1-3， 2007.

  13. Chang WT. siRNA as a therapeutic tool. The 2006 Spring Conference of Formosan Medical Association， Tainan， May 6-7， 2006. (臺灣醫學會95年春季學術演講)

  14. Teng CF， Hung CF， Wu RH， Huang LY， Cheng TL， and Chang WT. A novel siRNA validation system for screening and identification of effective RNAi probes in mammalian cells. Fourteenth Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， January 18-20， 2006. (第十四屆分子生物新知研討會優秀壁報獎)

  15. Cheng TL， Chen SZ， Liu CI， and Chang WT. A membrane transporter protein MtpA is required for culmination during multicellular development in Dictyostelium discoideum. Thirteenth Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， January 2-4， 2005. (第十三屆分子生物新知研討會優秀壁報獎)

  16. Chang WT. Application of RNA interference in medical therapeutics. Symposium of State-of-the-Art in Male Reproduction， Tainan， March 6， 2004.

  17. Cheng TL， Chang WW， Su IJ， Lai MD， Huang WY， Lei HY， and Chang WT. Therapeutic inhibition of hepatitis B virus expression and replication in mice by RNA interference. Twelfth Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， February 2-4， 2004. (第十二屆分子生物新知研討會優秀壁報獎)

  18. Cheng TL， Chang WW， Su IJ， Lai MD， Huang WY， Lei HY， and Chang WT. Therapeutic inhibition of hepatitis B virus expression and replication by RNA interference. The Third Fall Camp of Taiwan Society for Biochemistry and Molecular Biology， Tainan， November 14-16， 2003. (台灣生物化學及分子生物學學會第三屆秋令營研討會優秀壁報獎)

  19. Lo SR， Huang YC， Chen YH， Wang CW， Liu CI， and Chang WT. A nonmitochondrial citrate synthase is required for the cell growth and multicellular development in Dictyostelium. Eleventh Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， January 20-22， 2003.

  20. Cheng TL， Chen SZ， Liu CI， and Chang WT. Membrane transporter protein MtpA required for culmination during development in Dictyostelium. Sixteenth Federation of Asian and Oceanian Biochemists and Molecular Biologists Inc (FAOBMB) Symposium， Taipei， September 20-22， 2002. (Excellence in Poster Presentation at the 16th FAOBMB Symposium)

  21. Liu CI， Chen SZ， Huang YC， and Chang WT. Dictyostelium leucine-rich repeat protein LrrA regulates developmental morphogenesis. Tenth Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， January 25-28， 2002. (第十屆分子生物新知研討會優秀壁報獎)

  22. Chang WT. The role of HPt module-containing protein RdeA in Dictyostelium development. Second NHRI Conference on Developmental Biology， Taoyuan， October 27-28， 2000.

  23. Chang WT. Molecular study of signal transduction and development in Dictyostelium. Seventh Symposium on Recent Advances in Cellular and Molecular Biology， Kenting， January 30-February 1， 1999.

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Updated: 2018.03.07