Ming-Derg Lai

Distinguished Professor

Professor Ming-Derg Lai

My research interests focus on the interactions between oncogenes and tumor suppressor genes, and how these intra-and extra-cellular interactions leading to cancer. To approach this question, specific cell lines with mutated oncogenes or tumor suppressor genes are introduced into syngeneic host, and the cell-cell interactions and tumorigenicity are studied. Our current studies are mainly on oncogenes neu and ras and tumor suppressor gene p53. We studied intracellular signal transduction pathways of these gene products and their relationships with metastasis and tumor formation. In addition, we are also interested in studing the linkage between genetic polymorphism and cancer susceptibility.


  1. Shan YS, Hsu HP, Lai MD, Yen MC, Fang JH, Weng TY, Chen YL. Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model. Oncol Rep. 2014 [Abstract]

  2. Shan YS, Chen YL, Lai MD, Hsu HP. Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer. Oncol Rep. 2014 [Abstract]

  3. Shan YS, Hsu HP, Lai MD, Yen MC, Luo YP, Chen YL. Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer. Oncol Rep. 2014 [Abstract]

  4. Weng TY, Yen MC, Huang CT, Hung JJ, Chen YL, Chen WC, Wang CY, Chang JY, Lai MD. DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model. Gene Ther. 2014 [Abstract]

  5. Chang HY, Liu HS, Lai MD, Tsai YS, Tzai TS, Cheng HL, Chow NH. Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON. Cancer Res. 2014 [Abstract]

  6. Hung YH, Chan YS, Chang YS, Lee KT, Hsu HP, Yen MC, Chen WC, Wang CY, Lai MD. Fatty acid metabolic enzyme acyl-CoA thioesterase?8 promotes the development of hepatocellular carcinoma. Oncol Rep. 2014 [Abstract]

  7. Wang SM, Lee YC, Ko CY, Lai MD, Lin DY, Pao PC, Chi JY, Hsiao YW, Liu TL, Wang JM. Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer's Disease. Mol Neurobiol. 2014 [Abstract]

  8. Weng TY, Huang SS, Yen MC, Lin CC, Chen YL, Lin CM, Chen WC, Wang CY, Chang JY, Lai MD. A novel cancer therapeutic using thrombospondin 1 in dendritic cells. Mol Ther. 2014 [Abstract]

  9. Wang YW, Li WM, Wu WJ, Chai CY, Liu HS, Lai MD, Chow NH. Potential Significance of EMP3 in Patients with Upper Urinary Tract Urothelial Carcinoma: Crosstalk with ErbB2-PI3K-Akt Pathway. J Urol. 2013 [Abstract]

  10. Huang HL, Hsu HP, Shieh SC, Chang YS, Chen WC, Cho CY, Teng CF, Su IJ, Hung WC, Lai MD. Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide. Mol Cancer Ther. 2013 [Abstract]

  11. Sun HY, Lin CC, Lee JC, Wang SW, Cheng PN, Wu IC, Chang TT, Lai MD, Shieh DB, Young KC. Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III. Gut. 2013 [Abstract]

  12. Yen MC, Weng TY, Chen YL, Lin CC, Chen CY, Wang CY, Chao HL, Chen CS, Lai MD. An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA. Cancer Gene Ther. 2013 [Abstract]

  13. Chao YM, Lai MD, Chan JY. Redox-sensitive endoplasmic reticulum stress and autophagy at rostral ventrolateral medulla contribute to hypertension in spontaneously hypertensive rats. Hypertension. 2013 [Abstract]

  14. Yen MC, Lai MD. Biolistic DNA delivery to mice with the low pressure gene gun. Methods Mol Biol. 2013 [Abstract]

  15. Huang TT, Yen MC, Lin CC, Weng TY, Chen YL, Lin CM, Lai MD. Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer. Cancer Sci. 2011 [Abstract]

  16. Lee JW, Liao PC, Young KC, Chang CL, Chen SS, Chang TT, Lai MD, Wang SW. Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein. J Proteome Res. 2011 [Abstract]

  17. Shan YS, Fang JH, Lai MD, Yen MC, Lin PW, Hsu HP, Lin CY, Chen YL. Establishment of an orthotopic transplantable gastric cancer animal model for studying the immunological effects of new cancer therapeutic modules. Mol Carcinog. 2011 [Abstract]

  18. Chang YS, Tsai CT, Huangfu CA, Huang WY, Lei HY, Lin CF, Su IJ, Chang WT, Wu PH, Chen YT, Hung JH, Young KC, Lai MD. ACSL3 and GSK-3帣 are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells. J Cell Biochem. 2011 [Abstract]

  19. Chen SY, Wu CL, Lai MD, Lin CC, Yo YT, Jou IM, Lee CH, Weng CT, Shiau AL, Wang CR. Amelioration of rat collagen-induced arthritis through CD4+ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy. Hum Gene Ther. 2011 [Abstract]

  20. Liu HS, Hsu PY, Lai MD, Chang HY, Ho CL, Cheng HL, Chen HT, Lin YJ, Wu TJ, Tzai TS, Chow NH. An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells. Carcinogenesis. 2010 [Abstract]

  21. Hsu HP, Shan YS, Lai MD, Lin PW. Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival. Cancer Biol Ther. 2010 [Abstract]

  22. Yang HJ, Yen MC, Lin CC, Lin CM, Chen YL, Weng TY, Huang TT, Wu CL, Lai MD. A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity. Exp Biol Med (Maywood). 2010 [Abstract]

  23. Hung JH, Yan CW, Su IJ, Wang HC, Lei HY, Lin WC, Chang WT, Huang W, Lu TJ, Lai MD. Hepatitis B virus surface antigen interacts with acid alpha-glucosidase and alters glycogen metabolism. Hepatol Res. 2010 [Abstract]

  24. Hsu HP, Shan YS, Jin YT, Lai MD, Lin PW. Loss of E-cadherin and beta-catenin is correlated with poor prognosis of ampullary neoplasms. J Surg Oncol. 2010 [Abstract]

  25. Lai MD, Chen CS, Yang CR, Yuan SY, Tsai JJ, Tu CF, Wang CC, Yen MC, Lin CC. An HDAC inhibitor enhances the antitumor activity of a CMV promoter-driven DNA vaccine. Cancer Gene Ther. 2010 [Abstract]

  26. Sun HY, Chen SF, Lai MD, Chang TT, Chen TL, Li PY, Shieh DB, Young KC. Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins. Clin Chim Acta. 2010 [Abstract]

  27. Chuang JY, Wu CH, Lai MD, Chang WC, Hung JJ. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. Int J Cancer. 2009 [Abstract]

  28. Lai MD, Yen MC, Lin CM, Tu CF, Wang CC, Lin PS, Yang HJ, Lin CC. The effects of DNA formulation and administration route on cancer therapeutic efficacy with xenogenic EGFR DNA vaccine in a lung cancer animal model. Genet Vaccines Ther. 2009 [Abstract]

  29. Yen MC, Lin CC, Chen YL, Huang SS, Yang HJ, Chang CP, Lei HY, Lai MD. A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA. Clin Cancer Res. 2009 [Abstract]

  30. Chen YL, Fang JH, Lai MD, Shan YS. Depletion of CD4(+)CD25(+) regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma. World J Gastroenterol. 2008 [Abstract]

  31. Ling P, Lu TJ, Yuan CJ, Lai MD. Biosignaling of mammalian Ste20-related kinases. Cell Signal. 2008 [Abstract]

  32. Lin CC, Yen MC, Lin CM, Huang SS, Yang HJ, Chow NH, Lai MD. Delivery of noncarrier naked DNA vaccine into the skin by supersonic flow induces a polarized T helper type 1 immune response to cancer. J Gene Med. 2008 [Abstract]

  33. Lin CC, Yang HJ, Tu CF, Lai MD. The opposing effects of lipopolysaccharide on the antitumor therapeutic efficacy of DNA vaccine. DNA Cell Biol. 2008 [Abstract]

  34. Hsieh YH, Su IJ, Wang HC, Tsai JH, Huang YJ, Chang WW, Lai MD, Lei HY, Huang W. Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1. Mol Cancer Res. 2007 [Abstract]

  35. Hsieh YH, Su IJ, Lei HY, Lai MD, Chang WW, Huang W. Differential endoplasmic reticulum stress signaling pathways mediated by iNOS. Biochem Biophys Res Commun. 2007 [Abstract]

  36. Lin CC, Tu CF, Yen MC, Chen MC, Hsieh WJ, Chang WC, Chang WT, Lai MD. Inhibitor of heat-shock protein 90 enhances the antitumor effect of DNA vaccine targeting clients of heat-shock protein. Mol Ther. 2007 [Abstract]

  37. Tu CF, Lin CC, Chen MC, Ko TM, Lin CM, Wang YC, Lai MD. Autologous neu DNA vaccine can be as effective as xenogenic neu DNA vaccine by altering administration route. Vaccine. 2007 [Abstract]

  38. Shiau AL, Lin YP, Shieh GS, Su CH, Wu WL, Tsai YS, Cheng CW, Lai MD, Wu CL. Development of a conditionally replicating pseudorabies virus for HER-2/neu-overexpressing bladder cancer therapy. Mol Ther. 2007 [Abstract]

  39. Lu TJ, Lai WY, Huang CY, Hsieh WJ, Yu JS, Hsieh YJ, Chang WT, Leu TH, Chang WC, Chuang WJ, Tang MJ, Chen TY, Lu TL, Lai MD. Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. J Biol Chem. 2006 [Abstract]

  40. Wang HC, Huang W, Lai MD, Su IJ. Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis. Cancer Sci. 2006 [Abstract]

  41. Lin YJ, Lai MD, Lei HY, Wing LY. Neutrophils and macrophages promote angiogenesis in the early stage of endometriosis in a mouse model. Endocrinology. 2006 [Abstract]

  42. Chang WW, Su IJ, Lai MD, Chang WT, Huang W, Lei HY. Toll-like receptor 4 plays an anti-HBV role in a murine model of acute hepatitis B virus expression. World J Gastroenterol. 2005 [Abstract]

  43. Cheng TL, Chang WW, Su IJ, Lai MD, Huang W, Lei HY, Chang WT. Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference. Biochem Biophys Res Commun. 2005 [Abstract]

  44. Huang TJ, Lu CC, Tsai JC, Yao WJ, Lu X, Lai MD, Liu HS, Shiau AL. Novel autoregulatory function of hepatitis B virus M protein on surface gene expression. J Biol Chem. 2005 [Abstract]

  45. Lu TJ, Huang CY, Yuan CJ, Lee YC, Leu TH, Chang WC, Lu TL, Jeng WY, Lai MD. Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3. J Inorg Biochem. 2005 [Abstract]

  46. Lai MD, Lin WC, Sun YM, Chang FL. Phosphorylated and hypoacetylated mutant p53 enhances cisplatin-induced apoptosis through caspase-9 pathway in the absence of transcriptional activation or translation. Int J Mol Med. 2005 [Abstract]

  47. Hung JH, Su IJ, Lei HY, Wang HC, Lin WC, Chang WT, Huang W, Chang WC, Chang YS, Chen CC, Lai MD. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J Biol Chem. 2004 [Abstract]

  48. Hsieh YH, Su IJ, Wang HC, Chang WW, Lei HY, Lai MD, Chang WT, Huang W. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis. 2004 [Abstract]

  49. Lin CC, Chou CW, Shiau AL, Tu CF, Ko TM, Chen YL, Yang BC, Tao MH, Lai MD. Therapeutic HER2/Neu DNA vaccine inhibits mouse tumor naturally overexpressing endogenous neu. Mol Ther. 2004 [Abstract]

  50. Tsai WC, Tsai ST, Ko JY, Jin YT, Li C, Huang W, Young KC, Lai MD, Liu HS, Wu LW. The mRNA profile of genes in betel quid chewing oral cancer patients. Oral Oncol. 2004 [Abstract]

  51. Chang WW, Su IJ, Lai MD, Chang WT, Huang W, Lei HY. The role of inducible nitric oxide synthase in a murine acute hepatitis B virus (HBV) infection model induced by hydrodynamics-based in vivo transfection of HBV-DNA. J Hepatol. 2003 [Abstract]

  52. Hsieh JL, Wu CL, Lai MD, Lee CH, Tsai CS, Shiau AL. Gene therapy for bladder cancer using E1B-55 kD-deleted adenovirus in combination with adenoviral vector encoding plasminogen kringles 1-5. Br J Cancer. 2003 [Abstract]

  53. Lai MD, Jiang MJ, Wing LY. Estrogen stimulates expression of p21Waf1/Cip1 in mouse uterine luminal epithelium. Endocrine. 2002 [Abstract]

  54. Guo YL, Chang HC, Tsai JH, Huang JC, Li C, Young KC, Wu LW, Lai MD, Liu HS, Huang W. Two UVC-induced stress response pathways in HeLa cells identified by cDNA microarray. Environ Mol Mutagen. 2002 [Abstract]

  55. Chang FL, Lai MD. Various forms of mutant p53 confer sensitivity to cisplatin and doxorubicin in bladder cancer cells. J Urol. 2001 [Abstract]

  56. Chen CC, Shieh B, Jin YT, Liau YE, Huang CH, Liou JT, Wu LW, Huang W, Young KC, Lai MD, Liu HS, Li C. Microarray profiling of gene expression patterns in bladder tumor cells treated with genistein. J Biomed Sci. 2001 [Abstract]

  57. Chen SA, Tsai MH, Wu FT, Hsiang A, Chen YL, Lei HY, Tzai TS, Leung HW, Jin YT, Hsieh CL, Hwang LH, Lai MD. Induction of antitumor immunity with combination of HER2/neu DNA vaccine and interleukin 2 gene-modified tumor vaccine. Clin Cancer Res. 2000 [Abstract]

  58. Lai MD, Lee LR, Cheng KS, Wing LY. Expression of proliferating cell nuclear antigen in luminal epithelium during the growth and regression of rat uterus. J Endocrinol. 2000 [Abstract]

  59. Chang FL, Lai MD. The relationship between p53 status and anticancer drugs-induced apoptosis in nine human bladder cancer cell lines. Anticancer Res. 2000 [Abstract]

  60. Chang FL, Ling YF, Lai MD. Exogenous mutant p53 DNA enhanced cisplatin-induced apoptosis in TSGH-8301 human bladder cancer cells. Anticancer Res. 2000 [Abstract]

  61. Wang SL, Lai MD, Huang JD. G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab Dispos. 1999 [Abstract]

  62. Huang JD, Guo WC, Lai MD, Guo YL, Lambert GH. Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese. Drug Metab Dispos. 1999 [Abstract]

  63. Su HJ, Guo YL, Lai MD, Huang JD, Cheng Y, Christiani DC. The NAT2* slow acetylator genotype is associated with bladder cancer in Taiwanese, but not in the Black Foot Disease endemic area population. Pharmacogenetics. 1998 [Abstract]

  64. Hwang WJ, Lai ML, Tsai TT, Lai MD. Genetic polymorphism of monoamine oxidase B and susceptibility of Parkinson's disease. Zhonghua Yi Xue Za Zhi (Taipei). 1997 [Abstract]

  65. Chen CH, Lai ML, Lai MD, Huang JD. Apolipoprotein B gene polymorphisms in Taiwanese ischemic stroke patients. J Formos Med Assoc. 1997 [Abstract]

  66. Wu JD, Hsueh HC, Huang WT, Liu HS, Leung HW, Ho YR, Lin MT, Lai MD. The inducible lactose operator-repressor system is functional in the whole animal. DNA Cell Biol. 1997 [Abstract]

  67. Lee JC, Wang ST, Lai MD, Lin YJ, Yang HB. K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers. Anticancer Res. 1996 [Abstract]

  68. Lee JC, Lee TS, Ho HY, Hsueh HC, Huang WT, Ho YR, Lai MD. Expression pattern of nuclear p53 is unique in COS-1 cells. Anticancer Res. 1996 [Abstract]

  69. Tseng CY, Wang SL, Lai MD, Lai ML, Huang JD. Formation of morphine from codeine in Chinese subjects of different CYP2D6 genotypes. Clin Pharmacol Ther. 1996 [Abstract]

  70. Young KC, Shi GY, Chang YF, Chang BI, Chang LC, Lai MD, Chuang WJ, Wu HL. Interaction of streptokinase and plasminogen. Studied with truncated streptokinase peptides. J Biol Chem. 1995 [Abstract]

  71. Lee JC, Lin PW, Lin YJ, Lai J, Yang HB, Lai MD. Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections. J Formos Med Assoc. 1995 [Abstract]

  72. Wang SL, Lai MD, Lai ML, Huang JD. R296C and other CYP2D6 mutations in Chinese. Pharmacogenetics. 1995 [Abstract]

  73. Lai ML, Wang SL, Lai MD, Lin ET, Tse M, Huang JD. Propranolol disposition in Chinese subjects of different CYP2D6 genotypes. Clin Pharmacol Ther. 1995 [Abstract]

  74. Long SB, Ho HY, Chen CL, Lai MD. Complex of simian virus large T antigen and p53 can bind DNA specifically. Anticancer Res. 1995 [Abstract]

  75. Cheng YT, Li YL, Wu JD, Long SB, Tzai TS, Tzeng CC, Lai MD. Overexpression of MDM-2 mRNA and mutation of the p53 tumor suppressor gene in bladder carcinoma cell lines. Mol Carcinog. 1995 [Abstract]

  76. Lin SJ, Ko YH, Wang WP, Lai MD, Lai ML. Population genetic study of selected tetranucleotide repeat DNA polymorphisms on chromosomes Y and 12. J Formos Med Assoc. 1995 [Abstract]

  77. Wang SL, Huang J, Lai MD, Tsai JJ. Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese. Pharmacogenetics. 1995 [Abstract]

  78. Wang SL, Huang JD, Lai MD, Liu BH, Lai ML. Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6. Clin Pharmacol Ther. 1993 [Abstract]

  79. Yuan JN, Liu BH, Lee H, Shaw YT, Chiou ST, Chang WC, Lai MD. Release of the p53-induced repression on thymidine kinase promoter by single p53-binding sequence. Biochem Biophys Res Commun. 1993 [Abstract]

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Updated: 2014.11.20