國立成功大學醫學院生化所

特聘教授

吳昭良 博士

Professor Chao-Liang Wu

English Main Page

研究方向

研究興趣

開授課程

Publications:

  1. Su BH, Tseng YL, Shieh GS, Chen YC, Wu P, Shiau AL, Wu CL. Overexpression of prothymosin α antagonizes TGF-β signalling to promote the development of emphysema. The Journal of pathology. 2015 [Abstract]

  2. Su BH, Shieh GS, Tseng YL, Shiau AL, Wu CL. Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity. Oncotarget. 2015 [Abstract]

  3. Su YC, Ou HY, Wu HT, Wu P, Chen YC, Su BH, Shiau AL, Chang CJ, Wu CL. Prothymosin-α Overexpression Contributes to the Development of Insulin Resistance. J Clin Endocrinol Metab. 2015 [Abstract]

  4. Peng JS, Chen SY, Wu CL, Chong HE, Ding YC, Shiau AL, Wang CR. Amelioration of experimental autoimmune arthritis through targeting synovial fibroblasts by the intra-articular delivery of microRNA-140-3p and -5p. Arthritis Rheumatol. 2015 [Abstract]

  5. Li YR, Chen DY, Chu CL, Li S, Chen YK, Wu CL, Lin CC. Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis. J Nutr Biochem. 2015 [Abstract]

  6. Leu CH, Yang ML, Chung NH, Huang YJ, Su YC, Chen YC, Lin CC, Shieh GS, Chang MY, Wang SW, Chang Y, Chao J, Chao L, Wu CL, Shiau AL. Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin. Antimicrob Agents Chemother. 2015 [Abstract]

  7. Chen SY, Shiau AL, Wu CL, Wang CR. Amelioration of experimental arthritis by intra-articular injection of an epidermal growth factor receptor tyrosine kinase inhibitor. Clin Exp Rheumatol. 2015 [Abstract]

  8. Lu CS, Hsieh JL, Lin CY, Tsai HW, Su BH, Shieh GS, Su YC, Lee CH, Chang MY, Wu CL, Shiau AL. Potent antitumor activity of Oct4 and hypoxia dual-regulated oncolytic adenovirus against bladder cancer. Gene Ther. 2015 [Abstract]

  9. Chen SY, Shiau AL, Li YT, Lin CC, Jou IM, Liu MF, Wu CL, Wang CR. Transcription factor snail regulates tumor necrosis factor α-mediated synovial fibroblast activation in the rheumatoid joint. Arthritis Rheumatol. 2015 [Abstract]

  10. Ou HY, Wu HT, Lu FH, Su YC, Hung HC, Wu JS, Yang YC, Wu CL, Chang CJ. Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway. J Mol Endocrinol. 2014 [Abstract]

  11. Chen YF, Wang SH, Chang SJ, Shiau AL, Her LS, Shieh GS, Chen CF, Chang CC, Su YC, Wu CL, Wu TS. Zhankuic acid A as a novel JAK2 inhibitor for the treatment of concanavalin A-induced hepatitis. Biochem Pharmacol. 2014 [Abstract]

  12. Tsai YS, Jou YC, Tung CL, Lin CT, Shen CH, Chen SY, Tsai HT, Lai CL, Wu CL, Tzai TS. Loss of nuclear prothymosin-α expression is associated with disease progression in human superficial bladder cancer. Virchows Arch. 2014 [Abstract]

  13. Chen YF, Shiau AL, Wang SH, Yang JS, Chang SJ, Wu CL, Wu TS. Zhankuic acid A isolated from Taiwanofungus camphoratus is a novel selective TLR4/MD-2 antagonist with anti-inflammatory properties. J Immunol. 2014 [Abstract]

  14. Chang MY, Yang YS, Tsai ML, Lee CH, Chang CJ, Shiau AL, Wu CL. Adenovirus-mediated prothymosin α gene transfer inhibits the development of atherosclerosis in ApoE-deficient mice. Int J Biol Sci. 2014 [Abstract]

  15. Weng WT, Huang SC, Ma YL, Chan HH, Lin SW, Wu JC, Wu CY, Wen ZH, Wang EM, Wu CL, Tai MH. α-Melanocyte-stimulating hormone inhibits angiogenesis through attenuation of VEGF/VEGFR2 signaling pathway. Biochim Biophys Acta. 2014 [Abstract]

  16. Lin HC, Wu CL, Chen YL, Huang JS, Wong TY, Yuan K. High-level β1-integrin expression in a subpopulation of highly tumorigenic oral cancer cells. Clin Oral Investig. 2014 [Abstract]

  17. Hsieh JL, Shiau AL, Lee CH, Yang SJ, Lee BO, Jou IM, Wu CL, Chen SH, Shen PC. CD8+ T cell-induced expression of tissue inhibitor of metalloproteinses-1 exacerbated osteoarthritis. Int J Mol Sci. 2013 [Abstract]

  18. K Sivashanmugan, JD Liao, JW You, Wu CL. Focused-ion-beam-fabricated Au/Ag multilayered nanorod array as SERS-active substrate for virus strain detection. Sensors and Actuators B: Chemical. 2013 [Abstract]

  19. Wu HT, Lu FH, Ou HY, Su YC, Hung HC, Wu JS, Yang YC, Wu CL, Chang CJ. The role of hepassocin in the development of non-alcoholic fatty liver disease. J Hepatol. 2013 [Abstract]

  20. Su BH, Tseng YL, Shieh GS, Chen YC, Shiang YC, Wu P, Li KJ, Yen TH, Shiau AL, Wu CL. Prothymosin α overexpression contributes to the development of pulmonary emphysema. Nat Commun. 2013 [Abstract]

  21. JTsai YS1, Chen YH, Cheng PC, Tsai HT, Shiau AL, Tzai TS, Wu CL. TGF-β1 conjugated to gold nanoparticles results in protein conformational changes and attenuates the biological function. Small. 2013 [Abstract]

  22. Jou YC, Tsai YS, Hsieh HY, Chen SY, Tsai HT, Chen KJ, Wang ST, Shiau AL, Wu CL, Tzai TS. Plasma thymosin-α1 level as a potential biomarker in urothelial and renal cell carcinoma. Urol Oncol. 2013 [Abstract]

  23. Li YT, Chen SY, Wang CR, Liu MF, Lin CC, Jou IM, Shiau AL, Wu CL. Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223. Arthritis Rheum. 2012 [Abstract]

  24. Hsieh JL, Lu CS, Huang CL, Shieh GS, Su BH, Su YC, Lee CH, Chang MY, Wu CL, Shiau AL. Acquisition of an enhanced aggressive phenotype in human lung cancer cells selected by suboptimal doses of cisplatin following cell deattachment and reattachment. Cancer Lett. 2012 [Abstract]

  25. Huang YJ, Shiau AL, Chen SY, Chen YL, Wang CR, Tsai CY, Chang MY, Li YT, Leu CH, Wu CL. Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering. Eur Cell Mater. 2012 [Abstract]

  26. Lin YY, Liao JD, Yang ML, Wu CL. Target-size embracing dimension for sensitive detection of viruses with various sizes and influenza virus strains. Biosens Bioelectron. 2012 [Abstract]

  27. Chen SY, Shiau AL, Li YT, Lin YS, Lee CH, Wu CL, Wang CR. Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene. Gene Ther. 2012 [Abstract]

  28. Shiau AL, Shen YT, Hsieh JL, Wu CL, Lee CH. Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor. Environ Toxicol. 2012 [Abstract]

  29. Feng YH, Wu CL, Shiau AL, Lee JC, Chang JG, Lu PJ, Tung CL, Feng LY, Huang WT, Tsao CJ. MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. Int J Mol Med. 2012 [Abstract]

  30. Yang ML, Chen YH, Wang SW, Huang YJ, Leu CH, Yeh NC, Chu CY, Lin CC, Shieh GS, Chen YL, Wang JR, Wang CH, Wu CL, Shiau AL. Galectin-1 binds to influenza virus and ameliorates influenza virus pathogenesis. J Virol. 2011 [Abstract]

  31. Lee CH, Hsieh JL, Wu CL, Shiau AL. B cells are required for tumor-targeting Salmonella in host. Appl Microbiol Biotechnol. 2011 [Abstract]

  32. Chen SY, Wu CL, Lai MD, Lin CC, Yo YT, Jou IM, Lee CH, Weng CT, Shiau AL, Wang CR. Amelioration of rat collagen-induced arthritis through CD4+ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy. Hum Gene Ther. 2011 [Abstract]

  33. Chang YS, Lin CF, Wu CL, Kuo PY, Wu FS, Shieh CC, Gean PW, Chen ST, Chen MS, Wu WC, Tai MH, Tseng SH. Mechanisms underlying benzyl alcohol cytotoxicity (Triamcinolone acetonide preservative) in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2011 [Abstract]

  34. Shen PC, Shiau AL, Jou IM, Lee CH, Tai MH, Juan HY, Lin PR, Liu GS, Wu CL, Hsieh JL. Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis. Exp Biol Med (Maywood). 2011 [Abstract]

  35. Lee CH, Hsieh JL, Wu CL, Shiau AL. T cell augments the antitumor activity of tumor-targeting Salmonella. Appl Microbiol Biotechnol. 2011 [Abstract]

  36. Feng YH, Wu CL, Tsao CJ, Chang JG, Lu PJ, Yeh KT, Uen YH, Lee JC, Shiau AL. Deregulated expression of sprouty2 and microRNA-21 in human colon cancer: Correlation with the clinical stage of the disease. Cancer Biol Ther. 2011 [Abstract]

  37. Feng YH, Tsao CJ, Wu CL, Chang JG, Lu PJ, Yeh KT, Shieh GS, Shiau AL, Lee JC. Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells. Cancer Sci. 2010 [Abstract]

  38. Lin HY, Wu CL, Huang CC. The Akt-endothelial nitric oxide synthase pathway in lipopolysaccharide preconditioning-induced hypoxic-ischemic tolerance in the neonatal rat brain. Stroke. 2010 [Abstract]

  39. Shiau AL1, Teo ML, Chen SY, Wang CR, Hsieh JL, Chang MY, Chang CJ, Chao J, Chao L, Wu CL, Lee CH. Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin. BMC Cancer. 2010 [Abstract]

  40. Wang CR, Shiau AL, Chen SY, Cheng ZS, Li YT, Lee CH, Yo YT, Lo CW, Lin YS, Juan HY, Chen YL, Wu CL. Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis. Gene Ther. 2010 [Abstract]

  41. Hsieh JL, Shen PC, Shiau AL, Jou IM, Lee CH, Wang CR, Teo ML, Wu CL. Intra-articular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis. J Orthop Res. 2010 [Abstract]

  42. Yang HJ, Yen MC, Lin CC, Lin CM, Chen YL, Weng TY, Huang TT, Wu CL, Lai MD. A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity. Exp Biol Med (Maywood). 2010 [Abstract]

  43. Tsai YS, Shiau AL, Chen YF, Tsai HT, Tzai TS, Wu CL. Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy. Cancer Gene Ther. 2010 [Abstract]

  44. Lee CH, Wu CL, Shiau AL. Toll-like receptor 4 signaling promotes tumor growth. J Immunother. 2010 [Abstract]

  45. Chen SY, Shiau AL, Shieh GS, Su CH, Lee CH, Lee HL, Wang CR, Wu CL. Amelioration of experimental arthritis by a telomerase-dependent conditionally replicating adenovirus that targets synovial fibroblasts. Arthritis Rheum. 2009 [Abstract]

  46. Yo YT, Shieh GS, Hsu KF, Wu CL, Shiau AL. Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway. J Agric Food Chem. 2009 [Abstract]

  47. Jou YC, Tung CL, Tsai YS, Shen CH, Syue-Yi C, Shiau AL, Tsai HT, Wu CL, Tzai TS. Prognostic relevance of prothymosin-alpha expression in human upper urinary tract transitional cell carcinoma. Urology. 2009 [Abstract]

  48. Sung RJ, Chen SH, Luo CY, Wang JN, Wu CL, Chen YH, Su RJ, Li HJ, Tsai ML. Enhancement of vascular formation but not improvement of ventricular function of infarcted rat hearts by a high dose of adenovirus-carried VEGF transgene. Chin J Physiol. 2009 [Abstract]

  49. Su WC, Liu WL, Cheng CW, Chou YB, Hung KH, Huang WH, Wu CL, Li YT, Shiau AL, Lai MY. Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities. FEBS Lett. 2009 [Abstract]

  50. Wu HW, Huang YC, Wu CL, Lee GB. Ribavirin enhances interferon signaExploitation of a new microfluidic chip in the formation of emulsion droplets for gene delivery.ling via stimulation of mTOR and p53 activities. Microfluidics and Nanofluidics. 2009 [Abstract]

  51. Tsai YS, Shiau AL, Chen YF, Tsai HT, Lee HL, Tzai TS, Wu CL. Enhancement of antitumor immune response by targeted interleukin-12 electrogene transfer through antiHER2 single-chain antibody in a murine bladder tumor model. Vaccine. 2009 [Abstract]

  52. Liu YF, Chen HI, Wu CL, Kuo YM, Yu L, Huang AM, Wu FS, Chuang JI, Jen CJ. Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I. J Physiol. 2009 [Abstract]

  53. Lee CH, Wu CL, Chen SH, Shiau AL. Humoral immune responses inhibit the antitumor activities mediated by Salmonella enterica serovar choleraesuis. J Immunother. 2009 [Abstract]

  54. Hsu KF, Wu CL, Huang SC, Wu CM, Hsiao JR, Yo YT, Chen YH, Shiau AL, Chou CY. Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells. Autophagy. 2009 [Abstract]

  55. Hsieh JL, Lee CH, Teo ML, Lin YJ, Huang YS, Wu CL, Shiau AL. Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma. Cancer Sci. 2009 [Abstract]

  56. Hsieh JL, Shen PC, Shiau AL, Jou IM, Lee CH, Teo ML, Wang CR, Chao J, Chao L, Wu CL. Adenovirus-mediated kallistatin gene transfer ameliorates disease progression in a rat model of osteoarthritis induced by anterior cruciate ligament transection. Hum Gene Ther. 2009 [Abstract]

  57. Tsai YS, Jou YC, Lee GF, Chen YC, Shiau AL, Tsai HT, Wu CL, Tzai TS. Aberrant prothymosin-alpha expression in human bladder cancer. Urology. 2009 [Abstract]

  58. Chang CC, Shieh GS, Wu P, Lin CC, Shiau AL, Wu CL. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res. 2008 [Abstract]

  59. Wang CR, Shiau AL, Chen SY, Lin LL, Tai MH, Shieh GS, Lin PR, Yo YT, Lee CH, Kuo SM, Liu MF, Jou IM, Yang CY, Shen PC, Lee HL, Wu CL. Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN gene transfer. Arthritis Rheum. 2008 [Abstract]

  60. Hsu KF, Wu CL, Huang SC, Hsieh JL, Huang YS, Chen YF, Shen MR, Chung WJ, Chou CY, Shiau AL. Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy. Cancer Gene Ther. 2008 [Abstract]

  61. Chang MY, Shiau AL, Chen YH, Chang CJ, Chen HH, Wu CL. Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice. Cancer Sci. 2008 [Abstract]

  62. Chang YS, Wu CL, Tseng SH, Kuo PY, Tseng SY. In vitro benzyl alcohol cytotoxicity: implications for intravitreal use of triamcinolone acetonide. Exp Eye Res. 2008 [Abstract]

  63. Chang YS, Chen WC, Tseng SH, Sze CI, Wu CL. Subconjunctival mitomycin C before pterygium excision: an ultrastructural study. Cornea. 2008 [Abstract]

  64. Lee CH, Wu CL, Shiau AL. Toll-like receptor 4 mediates an antitumor host response induced by Salmonella choleraesuis. Clin Cancer Res. 2008 [Abstract]

  65. Wu CL, Shieh GS, Chang CC, Yo YT, Su CH, Chang MY, Huang YH, Wu P, Shiau AL. Tumor-selective replication of an oncolytic adenovirus carrying oct-3/4 response elements in murine metastatic bladder cancer models. Clin Cancer Res. 2008 [Abstract]

  66. Lee CH, Wu CL, Shiau AL. Salmonella choleraesuis as an anticancer agent in a syngeneic model of orthotopic hepatocellular carcinoma. Int J Cancer. 2008 [Abstract]

  67. Wang CR, Chen SY, Shiau AL, Wu CL, Jou IM, Chao L, Chao J. Upregulation of kallistatin expression in rheumatoid joints. J Rheumatol. 2007 [Abstract]

  68. Yo YT, Hsu KF, Shieh GS, Lo CW, Chang CC, Wu CL, Shiau AL. Coexpression of Flt3 ligand and GM-CSF genes modulates immune responses induced by HER2/neu DNA vaccine. Cancer Gene Ther. 2007 [Abstract]

  69. Chen YH, Tsai CY, Huang PY, Chang MY, Cheng PC, Chou CH, Chen DH, Wang CR, Shiau AL, Wu CL. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharm. 2007 [Abstract]

  70. Chu CY, Wang SY, Chen ZW, Chien MS, Huang JP, Chen JJ, Hong LS, Shiau AL, Tsai JL, Wu CL. Heterologous protection in pigs induced by a plasmid-cured and crp gene-deleted Salmonella choleraesuis live vaccine. Vaccine. 2007 [Abstract]

  71. Chang YS, Wu CL, Tseng SH, Kuo PY, Tseng SY. Cytotoxicity of triamcinolone acetonide on human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007 [Abstract]

  72. Shiau AL, Chen SY, Chang MY, Su CH, Chung SY, Yo YT, Wang CR, Wu CL. Prothymosin α lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis. J Immunol. 2007 [Abstract]

  73. Tsai CY, Shiau AL, Chen SY, Chen YH, Cheng PC, Chang MY, Chen DH, Chou CH, Wang CR, Wu CL. Amelioration of collagen-induced arthritis in rats by nanogold. Arthritis Rheum. 2007 [Abstract]

  74. Lee CH, Wu CL, Shiau AL. Hypoxia-induced cytosine deaminase gene expression for cancer therapy. Hum Gene Ther. 2007 [Abstract]

  75. Shiau AL, Lin YP, Shieh GS, Su CH, Wu WL, Tsai YS, Cheng CW, Lai MD, Wu CL. Development of a conditionally replicating pseudorabies virus for HER-2/neu-overexpressing bladder cancer therapy. Mol Ther. 2007 [Abstract]

  76. Chen YC, Chang MY, Shiau AL, Yo YT, Wu CL. Mitochondrial ribosomal protein S36 delays cell cycle progression in association with p53 modification and p21WAF1/CIP1 expression. J Cell Biochem. 2007 [Abstract]

  77. Shieh GS, Shiau AL, Yo YT, Lin PR, Chang CC, Tzai TS, Wu CL. Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model. Cancer Res. 2006 [Abstract]

  78. Chang YS, Tseng SY, Tseng SH, Wu CL, Chen MF. Triamcinolone acetonide suspension toxicity to corneal endothelial cells. J Cataract Refract Surg. 2006 [Abstract]

  79. Chang YS, Tseng SY, Tseng SH, Wu CL. Cytotoxicity of lidocaine or bupivacaine on corneal endothelial cells in a rabbit model. Cornea. 2006 [Abstract]

  80. Tzai TS, Tsai YS, Shiau AL, Wu CL, Shieh GS, Tsai HT. Urine prothymosin-alpha as novel tumor marker for detection and follow-up of bladder cancer. Urology. 2006 [Abstract]

  81. Shiau AL, Chen CC, Yo YT, Chu CY, Wang SY, Wu CL. Enhancement of humoral and cellular immune responses by an oral Salmonella choleraesuis vaccine expressing porcine prothymosin α. Vaccine. 2005 [Abstract]

  82. Tsai YS, Tzai TS, Chow NH, Wu CL. Frequency and clinicopathologic correlates of ErbB1, ErbB2, and ErbB3 immunoreactivity in urothelial tumors of upper urinary tract. Urology. 2005 [Abstract]

  83. Shieh DB, Cheng FY, Su CH, Yeh CS, Wu MT, Wu YN, Tsai CY, Wu CL, Chen DH, Chou CH. Aqueous dispersions of magnetite nanoparticles with NH3+ surfaces for magnetic manipulations of biomolecules and MRI contrast agents. Biomaterials. 2005 [Abstract]

  84. Lee CH, Wu CL, Tai YS, Shiau AL. Systemic administration of attenuated Salmonella choleraesuis in combination with cisplatin for cancer therapy. Mol Ther. 2005 [Abstract]

  85. Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L, Chao J. Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation. Arthritis Rheum. 2005 [Abstract]

  86. Li KJ, Shiau AL, Chiou YY, Yo YT, Wu CL. Transgenic overexpression of prothymosin α induces development of polycystic kidney disease. Kidney Int. 2005 [Abstract]

  87. Jou IM, Shiau AL, Chen SY, Wang CR, Shieh DB, Tsai CS, Wu CL. Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis. Arthritis Rheum. 2005 [Abstract]

  88. Shiau AL, Liu PS, Wu CL. Novel strategy for generation and titration of recombinant adeno-associated virus vectors. J Virol. 2005 [Abstract]

  89. Cheng FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, Wu MT, Shieh DB. Characterization of aqueous dispersions of Fe(3)O(4) nanoparticles and their biomedical applications. Biomaterials. 2005 [Abstract]

  90. Lee CH, Wu CL, Shiau AL. Systemic administration of attenuated Salmonella choleraesuis carrying thrombospondin-1 gene leads to tumor-specific transgene expression, delayed tumor growth and prolonged survival in the murine melanoma model. Cancer Gene Ther. 2005 [Abstract]

  91. Tsai CY, Shiau AL, Cheng PC, Shieh DB, Chen DH, Chou CH, Yeh CS, Wu CL. A Biological Strategy for Fabrication of Au/EGFP Nanoparticle Conjugates Retaining Bioactivity. Nano Letters 2004 [Abstract]

  92. Lee CH, Wu CL, Shiau AL. Endostatin gene therapy delivered by Salmonella choleraesuis in murine tumor models. J Gene Med. 2004 [Abstract]

  93. Jen CP, Chen YH, Fan CS, Yeh CS, Lin YC, Shieh DB, Wu CL, Chen DH, Chou CH. A nonviral transfection approach in vitro: the design of a gold nanoparticle vector joint with microelectromechanical systems. Langmuir. 2004 [Abstract]

  94. Hsiao JR, Jin YT, Tsai ST, Shiau AL, Wu CL, Su WC. Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. Br J Cancer. 2003 [Abstract]

  95. Hsieh JL, Wu CL, Lai MD, Lee CH, Tsai CS, Shiau AL. Gene therapy for bladder cancer using E1B-55 kD-deleted adenovirus in combination with adenoviral vector encoding plasminogen kringles 1-5. Br J Cancer. 2003 [Abstract]

  96. Hsieh JL, Wu CL, Lee CH, Shiau AL. Hepatitis B virus X protein sensitizes hepatocellular carcinoma cells to cytolysis induced by E1B-deleted adenovirus through the disruption of p53 function. Clin Cancer Res. 2003 [Abstract]

  97. Lu CY, Chou AK, Wu CL, Yang CH, Chen JT, Wu PC, Lin SH, Muhammad R, Yang LC. Gene-gun particle with pro-opiomelanocortin cDNA produces analgesia against formalin-induced pain in rats. Gene Ther. 2002 [Abstract]

  98. Chou AK, Muhammad R, Huang SM, Chen JT, Wu CL, Lin CR, Lee TH, Lin SH, Lu CY, Yang LC. Altered synaptophysin expression in the rat spinal cord after chronic constriction injury of sciatic nerve. Neurosci Lett. 2002 [Abstract]

  99. Shiau AL, Liu CW, Wang SY, Tsai CY, Wu CL. A simple selection system for construction of recombinant gD-negative pseudorabies virus as a vaccine vector. Vaccine. 2002 [Abstract]

  100. Shiau AL, Lin PR, Chang MY, Wu CL. Retrovirus-mediated transfer of prothymosin gene inhibits tumor growth and prolongs survival in murine bladder cancer. Gene Ther. 2001 [Abstract]

  101. Shiau AL, Chen YL, Liao CY, Huang YS, Wu CL. Prothymosin α enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis. Vaccine. 2001 [Abstract]

  102. Shiau AL, Lin CY, Tzai TS, Wu CL. Postoperative immuno-gene therapy of murine bladder tumor by in vivo administration of retroviruses expressing mouse interferon-gamma. Cancer Gene Ther. 2001 [Abstract]

  103. Shiau AL, Chu CY, Su WC, Wu CL. Vaccination with the glycoprotein D gene of pseudorabies virus delivered by nonpathogenic Escherichia coli elicits protective immune responses. Vaccine. 2001 [Abstract]

  104. Tzai TS, Shiau AL, Liu LL, Wu CL. Immunization with TGF-β antisense oligonucleotide-modified autologous tumor vaccine enhances the antitumor immunity of MBT-2 tumor-bearing mice through upregulation of MHC class I and Fas expressions. Anticancer Res. 2000 [Abstract]

  105. Tzai TS, Shiau AL, Wu CL, Tsai YS. Postoperative administration of interleukin-12 significantly enhances the anti-tumor immune response of MBT-2 bladder cancer bearing mice. Proc Natl Sci Counc Repub China B. 2000 [Abstract]

  106. Yang WH, Peng HH, Chang HC, Shen SY, Wu CL, Chang CH. An in vitro monitoring system for simulated thermal process in cryosurgery. Cryobiology. 2000 [Abstract]

  107. Wu CL, Wu P, Shiau AL. A computerized management system for cell bank. Anal Biochem. 1999 [Abstract]

  108. Wu CL, Leu TS, Chang TT, Shiau AL. Hepatitis C virus core protein fused to hepatitis B virus core antigen for serological diagnosis of both hepatitis C and hepatitis B infections by ELISA. J Med Virol. 1999 [Abstract]

  109. Chu CY, Shiau AL, Chang CH, Chang TJ, Lin CS, Wu CL. Evaluation of a gE-deleted TK-negative attenuated pseudorabies virus vaccine. Taiwan Journal of Veterinary Medicine and Animal Husbandry 1999

  110. Shiau AL, Yang HM, Wu P, Wu CL. Provision of positive and negative selections in retroviral vectors containing the cytosine deaminase gene. Gene Ther. 1998 [Abstract]

  111. Tzai TS, Shiau AL, Wu CL, Chow NH, Tsai YS. Modulating the antitumor immunity of MBT-2 murine bladder tumor bearing mice by postoperative administration of interferon-alpha. Anticancer Res. 1998 [Abstract]

  112. Tzai TS, Lin CI, Shiau AL, Wu CL. Antisense oligonucleotide specific for transforming growth factor β1 inhibit both in vitro and in vivo growth of MBT-2 murine bladder cancer. Anticancer Res. 1998 [Abstract]

  113. Shiau AL, Wu CL. The inhibitory effect of Staphylococcus epidermidis slime on the phagocytosis of murine peritoneal macrophages is interferon-independent. Microbiol Immunol. 1998 [Abstract]

  114. Wu CL, Shiau AL, Lin CS. Prothymosin alpha promotes cell proliferation in NIH3T3 cells. Life Sci. 1997 [Abstract]

  115. Tzai TS, Shiau AL, Lin CS, Wu CL, Lin JS. Modulation of the immunostimulating effect of autologous tumor vaccine by anti-TGF-β antibody and interferon-alpha on murine MBT-2 bladder cancer. Anticancer Res. 1997 [Abstract]

  116. Redhead NJ, Selfridge J, Wu CL, Melton DW. Mice with adenine phosphoribosyltransferase deficiency develop fatal 2,8-dihydroxyadenine lithiasis. Hum Gene Ther. 1989 [Abstract]

  117. Wu CL, Melton DW. Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. Nat Genet. 1993 [Abstract]

  118. Yang CR, Wu CL, Shiau AL, Tzai TS. The growth kinetics of bladder tumor following BCG treatment. Journal of Urology R.O.C. 1990 [Abstract]

  119. Li IC, Wu CL, Chu EH. Single-step selection of mammalian cell mutants deficient in CTP synthetase. Somat Cell Mol Genet. 1989 [Abstract]

  120. Wu CL, Shiau AL. Citation star: A microcomputer software package for management of biomedical references and preparation of literature citation. Trends in Biochemical Sciences 1988 [Abstract]

  121. Shiau AL, Wu CL, Huang KY. The effect of thymosin on experimental herpes simplex virus infections. Journal of the Formosan Medical Association. 1988 [Abstract]

  122. Pan IH, Wu CM, Wu CL. Appearance rate of fluorescent Y-body in healthy Chinese buccal epithelial cells and leukocytes with special reference to its value in sex determination. Journal of the Formosan Medical Association. 1978 [Abstract]

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Updated: 2015.11.13