國立成功大學醫學院生化所

特聘教授

莊偉哲 博士

Prof. W.J. Chuang

English Main Page

研究專長

研究方向

研究興趣

研究主題

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Publications:

  1. Lin CP, Kang KH, Lin TH, Wu MY, Liou HC, Chuang WJ, Sun WZ, Fu WM. Role of Spinal CXCL1 (GROα) in Opioid Tolerance: A Human-to-rodent Translational Study. Anesthesiology. 2014 [Abstract]

  2. Wang CC, Lai WC, Chuang WJ. Type I and II β-turns prediction using NMR chemical shifts. J Biomol NMR. 2014 [Abstract]

  3. Zheng PX, Chiang-Ni C, Wang SY, Tsai PJ, Kuo CF, Chuang WJ, Lin YS, Liu CC, Wu JJ. Arrangement and number of clustered regularly interspaced short palindromic repeat spacers are associated with erythromycin susceptibility in emm12, emm75 and emm92 of group A streptococcus. Clin Microbiol Infect. 2014 [Abstract]

  4. Lin CS, Chao SY, Hammel M, Nix JC, Tseng HL, Tsou CC, Fei CH, Chiou HS, Jeng US, Lin YS, Chuang WJ, Wu JJ, Wang S. Distinct structural features of the peroxide response regulator from group a streptococcus drive DNA binding. PLoS One. 2014 [Abstract]

  5. Lu SL, Tsai CY, Luo YH, Kuo CF, Lin WC, Chang YT, Wu JJ, Chuang WJ, Liu CC, Chao L, Chao J, Lin YS. Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group A streptococcal infection. Antimicrob Agents Chemother. 2013 [Abstract]

  6. Wang CH, Chiang-Ni C, Kuo HT, Zheng PX, Tsou CC, Wang S, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ. Peroxide responsive regulator PerR of group A Streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress. PLoS One. 2013 [Abstract]

  7. Chen YC, Cheng CH, Shiu JH, Chang YT, Chang YS, Huang CH, Lee JC, Chuang WJ. Expression in Pichia pastoris and characterization of echistatin, an RGD-containing short disintegrin. Toxicon. 2012 [Abstract]

  8. Cheng CH, Chen YC, Shiu JH, Chang YT, Chang YS, Huang CH, Chen CY, Chuang WJ. Dynamics and functional differences between dendroaspin and rhodostomin: insights into protein scaffolds in integrin recognition. Protein Sci. 2012 [Abstract]

  9. Chiang-Ni C, Zheng PX, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ. Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci. J Med Microbiol. 2012 [Abstract]

  10. Shiu JH, Chen CY, Chen YC, Chang YT, Chang YS, Huang CH, Chuang WJ. Effect of P to A mutation of the N-terminal residue adjacent to the Rgd motif on rhodostomin: importance of dynamics in integrin recognition. PLoS One. 2012 [Abstract]

  11. Chiang-Ni C, Wu AB, Liu CC, Chen KT, Lin YS, Chuang WJ, Fang HY, Wu JJ. Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan. J Microbiol Immunol Infect. 2011 [Abstract]

  12. Su YF, Chuang WJ, Wang SM, Chen WY, Chiang-Ni C, Lin YS, Wu JJ, Liu CC. The deficient cleavage of M protein-bound IgG by IdeS: insight into the escape of Streptococcus pyogenes from antibody-mediated immunity. Mol Immunol. 2011 [Abstract]

  13. Dai YC, Chuang WJ, Chua KY, Shieh CC, Wang JY. Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: insight into therapeutic potential. J Mol Med (Berl). 2011 [Abstract]

  14. Chu YP, Chang CH, Shiu JH, Chang YT, Chen CY, Chuang WJ. Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding. Protein Sci. 2011 [Abstract]

  15. Anangi R, Chen CC, Lin YW, Cheng YR, Cheng CH, Chen YC, Chu YP, Chuang WJ. Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3. Toxicon. 2010 [Abstract]

  16. Luo YH, Chuang WJ, Wu JJ, Lin MT, Liu CC, Lin PY, Roan JN, Wong TW, Chen YL, Lin YS. Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells. Lab Invest. 2010 [Abstract]

  17. Tsou CC, Chiang-Ni C, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ. Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes. Int J Med Microbiol. 2010 [Abstract]

  18. Chang CW, Tsai WH, Chuang WJ, Lin YS, Wu JJ, Liu CC, Tsai PJ, Lin MT. Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis. J Biol Chem. 2009 [Abstract]

  19. Chang CW, Wu SY, Chuang WJ, Lin YS, Wu JJ, Liu CC, Tsai PJ, Lin MT. The IL-8 production by Streptococcal pyrogenic exotoxin B. Exp Biol Med (Maywood). 2009 [Abstract]

  20. Chiang-Ni C, Zheng PX, Ho YR, Wu HM, Chuang WJ, Lin YS, Lin MT, Liu CC, Wu JJ. emm1/sequence type 28 strains of group A streptococci that express covR at early stationary phase are associated with increased growth and earlier SpeB secretion. J Clin Microbiol. 2009 [Abstract]

  21. Chen CY, Shiu JH, Hsieh YH, Liu YC, Chen YC, Chen YC, Jeng WY, Tang MJ, Lo SJ, Chuang WJ. Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: importance of the interactions between the D residue and integrin. Proteins. 2009 [Abstract]

  22. Su YF, Wang SM, Lin YL, Chuang WJ, Lin YS, Wu JJ, Lin MT, Liu CC. Changing epidemiology of Streptococcus pyogenes emm types and associated invasive and noninvasive infections in Southern Taiwan. J Clin Microbiol. 2009 [Abstract]

  23. Wang CC, Houng HC, Chen CL, Wang PJ, Kuo CF, Lin YS, Wu JJ, Lin MT, Liu CC, Huang W, Chuang WJ. Solution structure and backbone dynamics of streptopain: insight into diverse substrate specificity. J Biol Chem. 2009 [Abstract]

  24. Chiang-Ni C, Tsou CC, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ. The transcriptional terminator sequences downstream of the covR gene terminate covR/S operon transcription to generate covR monocistronic transcripts in Streptococcus pyogenes. Gene. 2008 [Abstract]

  25. Tsou CC, Chiang-Ni C, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ. An iron-binding protein, Dpr, decreases hydrogen peroxide stress and protects Streptococcus pyogenes against multiple stresses. Infect Immun. 2008 [Abstract]

  26. Hsu JF, Chuang WJ, Shiesh SC, Lin YS, Liu CC, Wang CC, Fu TF, Tsai JH, Tsai WL, Huang YJ, Hsieh YH, Wu JJ, Lin MT, Huang W. Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia. J Infect Dis. 2008 [Abstract]

  27. Wang SM, Lu IH, Lin YL, Lin YS, Wu JJ, Chuang WJ, Lin MT, Liu CC. The severity of Streptococcus pyogenes infections in children is significantly associated with plasma levels of inflammatory cytokines. Diagn Microbiol Infect Dis. 2008 [Abstract]

  28. Su CC, Lin YP, Cheng YJ, Huang JY, Chuang WJ, Shan YS, Yang BC. Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells. J Immunol. 2007 [Abstract]

  29. Luo YH, Kuo CF, Huang KJ, Wu JJ, Lei HY, Lin MT, Chuang WJ, Liu CC, Lin CF, Lin YS. Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis. Kidney Int. 2007 [Abstract]

  30. Chang CW, Tsai WH, Chuang WJ, Lin YS, Wu JJ, Liu CC, Tsai PJ, Lin MT. The fate of SPE B after internalization and its implication in SPEB-induced apoptosis. J Biomed Sci. 2007 [Abstract]

  31. Wang CC, Chen JH, Lai WC, Chuang WJ. 2DCSi: identification of protein secondary structure and redox state using 2D cluster analysis of NMR chemical shifts. J Biomol NMR. 2007 [Abstract]

  32. Lu TJ, Lai WY, Huang CY, Hsieh WJ, Yu JS, Hsieh YJ, Chang WT, Leu TH, Chang WC, Chuang WJ, Tang MJ, Chen TY, Lu TL, Lai MD. Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. J Biol Chem. 2006 [Abstract]

  33. Chiang-Ni C, Wang CH, Tsai PJ, Chuang WJ, Lin YS, Lin MT, Liu CC, Wu JJ. Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A streptococcus. Med Microbiol Immunol. 2006 [Abstract]

  34. Wang CC, Chen JH, Yin SH, Chuang WJ. Predicting the redox state and secondary structure of cysteine residues in proteins using NMR chemical shifts. Proteins. 2006 [Abstract]

  35. Chen CY, Cheng CH, Chen YC, Lee JC, Chou SH, Huang W, Chuang WJ. Preparation of amino-acid-type selective isotope labeling of protein expressed in Pichia pastoris. Proteins. 2006 [Abstract]

  36. Hsieh HC, Hsieh YH, Huang YH, Shen FC, Tsai HN, Tsai JH, Lai YT, Wang YT, Chuang WJ, Huang W. HHR23A, a human homolog of Saccharomyces cerevisiae Rad23, regulates xeroderma pigmentosum C protein and is required for nucleotide excision repair. Biochem Biophys Res Commun. 2005 [Abstract]

  37. Wang CH, Lin CY, Luo YH, Tsai PJ, Lin YS, Lin MT, Chuang WJ, Liu CC, Wu JJ. Effects of oligopeptide permease in group a streptococcal infection. Infect Immun. 2005 [Abstract]

  38. Tsai WH, Chang CW, Chuang WJ, Lin YS, Wu JJ, Liu CC, Chang WT, Lin MT. Streptococcal pyrogenic exotoxin B-induced apoptosis in a549 cells is mediated by a receptor- and mitochondrion-dependent pathway. Infect Immun. 2004 [Abstract]

  39. Shiu JH, Chen CY, Chang LS, Chen YC, Chen YC, Lo YH, Liu YC, Chuang WJ. Solution structure of gamma-bungarotoxin: the functional significance of amino acid residues flanking the RGD motif in integrin binding. Proteins. 2004 [Abstract]

  40. Jeng WY, Tsai YH, Chuang WJ. The catalase activity of Nalpha-acetyl-microperoxidase-8. J Pept Res. 2004 [Abstract]

  41. Yan JJ, Liu CC, Ko WC, Hsu SY, Wu HM, Lin YS, Lin MT, Chuang WJ, Wu JJ. Molecular analysis of group A streptococcal isolates associated with scarlet fever in southern Taiwan between 1993 and 2002. J Clin Microbiol. 2003 [Abstract]

  42. Chen CY, Luo SC, Kuo CF, Lin YS, Wu JJ, Lin MT, Liu CC, Jeng WY, Chuang WJ. Maturation processing and characterization of streptopain. J Biol Chem. 2003 [Abstract]

  43. Chuang WJ, Wu CH, Huang HN, Chen SH, Hsiao G, Lin CH, Sheu JR. Comparison of the binding character of triflavin on resting and activated alpha(IIb)beta(3) integrin in human platelets by electron microscopy. Thromb Res. 2003 [Abstract]

  44. Jeng WY, Chen CY, Chang HC, Chuang WJ. Expression and characterization of recombinant human cytochrome c in E. coli. J Bioenerg Biomembr. 2002 [Abstract]

  45. Liu PP, Chen YC, Li C, Hsieh YH, Chen SW, Chen SH, Jeng WY, Chuang WJ. Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a). Proteins. 2002 [Abstract]

  46. Huang BM, Ju SY, Wu CS, Chuang WJ, Sheu CC, Leu SF. Cordyceps sinensis and its fractions stimulate MA-10 mouse Leydig tumor cell steroidogenesis. J Androl. 2001 [Abstract]

  47. Jiang ST, Chiu SJ, Chen HC, Chuang WJ, Tang MJ. Role of alpha(3)beta(1) integrin in tubulogenesis of Madin-Darby canine kidney cells. Kidney Int. 2001 [Abstract]

  48. Jiang ST, Chuang WJ, Tang MJ. Role of fibronectin deposition in branching morphogenesis of Madin-Darby canine kidney cells. Kidney Int. 2000 [Abstract]

  49. Jiang ST, Chiang HC, Cheng MH, Yang TP, Chuang WJ, Tang MJ. Role of fibronectin deposition in cystogenesis of Madin-Darby canine kidney cells. Kidney Int. 1999 [Abstract]

  50. Shieh B, Su IJ, Chuang WJ, Li C. Dye-induced denaturation of DNA dissolved in water. Biotechniques. 1998 [Abstract]

  51. Chen H, Wu YI, Hsieh YL, Shi GY, Jiang MJ, Chang WC, Chuang WJ, Kan WM, Tang MJ, Jen CJ. Perturbation of platelet adhesion to endothelial cells by plasminogen activation in vitro. Thromb Haemost. 1997 [Abstract]

  52. Young KC, Shi GY, Chang YF, Chang BI, Chang LC, Lai MD, Chuang WJ, Wu HL. Interaction of streptokinase and plasminogen. Studied with truncated streptokinase peptides. J Biol Chem. 1995 [Abstract]


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Updated: 2014.11.19